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Tüberküloz Plörezi ve Adenozin Deaminaz

Pleural tuberculosis and adenosine deaminase.

Journal Name:

  • Selçuk Tıp Dergisi

Publication Year:

  • 2004

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Abstract (2. Language): 
İn purine pathvvay, adenosine deaminase is a cytoplasmic enzyme which changes adenosine into inosine and ammo-mum, deoxyadenosine into deoxyinosİne and ammonium cataiyzed irreversıbly. Activation of ADA ın human fluids is by two enzymes: ADAI and ADA2. IncreasedADA levels in tuberculosis pleural effusion have 9681-100 sensivity and ■ro83-100 specı vıty. ADA ın tuberculosis effusıons orıgınated from macrophages and monosit is mainly ADA2. ADA level also can be ıncreased ın ampiyem, lenfoproliteratif disorders and parapnömonic pleural effusions which have lymphocyte celi mostly
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Abstract (Original Language): 
Adenozin deaminaz (ADAJ; purin yıkım yolunda bulunan adenosini inosin ve amonyağa, deoxyadenosin'i deoxyino-sıne ve amonyağa dönüşümünü irreversibl katalizleyen sıtoplazmik bir enzimdir. İnsan biyolojik sıvılanndaki ADA aktıvitesi farklı başlıca iki izoenzimden kaynaklanır. Bunlar ADA I ve ADA2 şeklinde isimlendirilir. Tüberküloz plorezilerde sıvı ADA seviyesi artışı %8\-İ00 sensitMte ve %83-100'lük bir spesifisite gösterir. Tüberküloz effüzyoniarında ADA'nın başlıca kaynağı monosit -makrofaj hücrelerde sentezlenen ADA2'dir. Lenfosirden zengin plevra sıvı toplanmasına neden olan parapnömonik effüzyonlar, ampiyem ve lenfoproliferatif hastalıklarda da sıvı ADA seviyesi artışı olabilir.
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  • 3
123-127
  • Turkish

REFERENCES

References: 

1- Valdes L San Jose E. Afvares D. Sarandeses A Pase A Chomon B, et al Dıagnosıs of Che tuberculous pleurısy usıng the bıologıc paremeters adenosine deaminase. lysozyme and ınterferon gamma Chest 1993.103:458¬65
2- Valdes L AJvares D, Valle JM. Pose A San Jose E The eti-yology of pleural effusior^ ın an area wıth hıgh incıdence Of tuberculosis Chesi 1996;109:158-62
3- Valdes L Jose ES. Alvares D. Valle JM Adenosine deami¬nase |ADA) ısoenzymes analysis in pleural effusıons value role, and relevance to the orijin of ıncreased ADA ın tuber-culous pleurısy Eur Respır J 1996.9 747-51
4- Sıebert AF. Haynes J. VVıddleton R. Bass JB Tuberculous pleural effusıons. twenty year experıence Ches! 1991.99 883-6
5- Burgess U. Martız FJ. Roux IU, TaJjaord JJF ComDmed use of pleural adenosine deaminase wıth lymphocyte/neu-trophıl ratıo. Chest 1996;109:414-9
6- Berger HW, Wezıa E Tuberculous pleurısy. Chest 1973;63:88-92
7- Ouerol JM. Minguez J. Garcia-Santhez E. Farga MA Gımeno C. Garcia-de-Lomas J. Rapıd dıagnosıs of pleural tuberculosis by polymerase chain reactıon Am J Respır Cm Car Med 1995; 1 52|6): 1977-81.
8- Rodrıgues EP. Vvalton UP. Hemandez JJS. Pallares E. Rubı J. CastroDJ. et al. ADAl/ADAp ratıo ın pleural tubercu¬lous: an exellent dıagnostıc parameter ın pleural fluıd Respır Med 1999.93:816-21.
9- Vera Hernando HR, Masa Jımenez JF. Domınquez Juncal L, Perz Garcia-Buela J, Martin Egana MT. Fontan Bueso J. Meanıng and dıagnostic value of determimng the lysozyme level pleural fluıd Chest 1987;91:342-5
10- Vıllena V, Navarro-Gonzalvez JA. Garcıa-Benayas C, Munzanos JA Echave J. Lopez-En cuentra A el al. Rapıd automated determinatıon of adenosine deaminase and lysozyme for differentiating tuberculous and nontubercu-lous pleural effusions. Clin Chem I996;42|2J:2I8-21.
11- Muranıchi H. Nakashima M. Hırano H. Saıtoh T, Takahashi H, Tanaka K, et al. Simultaneous measurements and adenosine deaminase actıvıty and tuberculosteanc acıd ın pleural effusions for dıagnosis of tuberculous pleurıtis. Intern Med 1992;31:752-5.
12- Caminero JA Rodriguez de Castro F, Carillo T. Rodriguez Bermego JC. Cabrera P Diagnosıs of tuberculous by defection of specıfic IgG anti-antıgen 60 ın serum and plevral fluıd: Respıratıon 1993;60:58-62
13- Rıbera E. Ocana I, Martın ez-Vazquez JM, Rossel M. Espenol T. Rubibal A Hıgh level of interferon gamma in tuberculous pleural effusıon. Chest 1988,93.308-1 1.
14- Orphanıodou D. Gaga M. Rasidakis A Dımakou K, Toumbıs M. Latsı P. et al Tumour necrosıs factor, inter-leukın-1 and adenosine deaminase ın tuberulous pleural effusions Respır Med 1996;90(2).95-8
15- Van der Weyden MB. Kelley WN. Human adenosine deaminase:distribution and propertıes. J Biol Chem 1976;251:5448-56.
16- Van der Weyden MB. Baıley L. A micromethod for deter-mınatıng adenosine deaminase and purin nucleaside phosphon/lase activity in celi from perıpheral blood. Clin Chem Açta 1978;82:179-84.
17- Fischer D. Van der Meyden MB, Snyderman R, Kelly WN. A role for adenosine deaminase in human monocyte mat-uratıon. J Clin Invest 1976;58:399-407.
18- Piras MA Gakis C, Budroni M. Andreoni G. Adenosine deaminase activity in pleural effusions an aıd to differen-tıal dıagnosis BrMedJ 1978;2:1751-2.
19- Baganha MF. Pego A Uma MA Gaspar EV. Corderıo AR Serum and plevral deaminase; correction wıth lymphoctic polatrons Chest 1990;97:605-10.
20- Aktepe N. Erel Û, Koçyıgit A Sıtma hastalarında serum ADA guanaz, ürik asit düzeylerinin incelenmesi. Tukish Journal of Biochemıstry 1999;24( 1 ):26-9

21- Gıblett ER. Anderson JE. Cohen F, Pollara B, Meuvvıssen HJ Adenosine deaminase deficıency m two patıents wıth severely ımpaıred cellular ımmunıty Lancet 1972.2 1067¬9
22- Ratech H. Hırschorn R. Serum adenosine deaminase ın normals and ın a patıents with adenosine defıcıent-severe combıned ımpraıred celluiar ımrnumty Lancet 1972,2:1067-9
23- Gakıs C Adenosine deaminase [ADA) Isoenzymes ADA-i and ADÛ-? Dıagnosıs and bıologıcal role Eur Respır J 1996.9.632-3
24- Gakıs C Clıca G. Naıtana A Pirano D, Serru G Serum and pleural adenosine deaminase actvity Chest 1991;99:1555-6
25- Ozvaran MK. Okur HK. Özgel M, Ertugrul M, Baran R. Tüberküloz plorezı adenozin deaminaz ve izoenzimlerinin tanı değerliliği Toraks dergisi 2003; kabul edildi.
26- Marıtz FJ. Malan C. Le roux I. Adenosine deaminase estı-matıons ın the differentıatıon of pleural effusions. S Afr Med J 1982;62:556-8
27- Lee YCG. Rogers JT. Rodriguez RM, Miller KD. üght RW Adenosine deaminase level ın tubercuJous lymphocytıc pleural effusions. Chest 2001.120:356-6 1
28- Nıshıhara H. Akedo H Okada H. Multiple enzyme pattern of serum adenosine deaminase by ağar gel electrophore-sis. an evaluatıon of the dıagnostic value ın lung cancer Clin Chem Açta 1970;30:251-8.
29- Ungerre JPJ Oosthuizen HM. Rrtıef JH. Bıssbort SH Signıfıcance of adenosine deaminase activity and isoen-zymes ın tuberculous effusions Chest 1994.106:33-7
30- Shıbagakı T, Hasegava Y, Saıto H, Yamon S. Shimokata K Adenosdıne deaminase izozymes ın tuberculous pleural effusions J Lab Cim Med 1996;127:348-52
31 - Bonet M. Maymo J. Arnau D. Noueroles A Curull V. Carbonell J Adenosine deaminase actıvıty m rheumatoıd pleural effusion Annal Rheum Dıs 1989;48:789.
32- Anten RJ. Kıempema V. Slaats EH. VVagmaar JPM Adenosine deaminase activity. not dıagnostic for tubercu¬lous pleurısy EurJRespır. Dis 1987;71:15-8
33- Raintavvan P. Chaovvalit P, vVongsangıem M. Rojanaraweewong P. Diagnostıc value of pleural fluıd adenosine deaminase in tuberculous pleuntıs wıth refer-ence to HIV coinfection and a Bayesian Analysis Chest 1999,166 [1) 97-103.
34- Banales JL Pıneda PR. Fıtzgerald JM. Rubio HR. Selman M. Salazar-Lezema M Adenosine deaminase ın the dıagnosıs of tuberculous pleural effusions; a report of 218 patıents and revıevv of the literatüre Chest 1991;99:355-7
35- Sudre P. Ten Dam G Kochı A Tuberculous a global overvıevv of the sıtuatıon today Bull Word Health Organ 1992.70:149-59.
36- Fry MD. Posik O. Shan SA. Tuberculous pleursy ıs more common in AİDS non-AIDS patient with tuberculous Chest 1997,112:393-7.
37- Ouerol JM, Barbe F. Manresa F, Estaban L Canete C Low value of adenosine deaminase in tuberculous pleural effu¬sıons. EurRespirJ 1990;3:586-7.
38- Orrıols R. Coioma R. Ferrer J. Vıdal R, Morell F Adenosine deaminase in tuberculous pleural effusion. Chest 1994;106[5):1663
39- Görgüner M, Cerci M, Görgüner I. Determinatıon of adenosine deaminase activity and its ısoenzymes for dıag¬nosis of pleural effusions. Respırology 2000;5:321-4

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