Abstract
Bioassay guided fractionation of the acetonic extract of Helichrysum melanacme using human Influenza virus type A and a drug-sensitive strain of Mycobacterium tuberculosis in vitro resulted in the isolation of 2 4',6'-trihydroxy-3'-prenylchalcone (1) and 4',6',5''-trihydroxy-6'',6''-dimethyldihydropyrano[2'',3''-2',3'] chalcone (2) as active constituents. 3-O-methylquercetin and quercetin were also isolated but were inactive against the microorganisms tested in this study.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetone / chemistry
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Antitubercular Agents / pharmacology*
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Antiviral Agents / pharmacology*
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Chalcones / chemistry
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Chalcones / isolation & purification
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Chalcones / pharmacology*
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Helichrysum / chemistry*
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Influenza A virus / drug effects*
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Microbial Sensitivity Tests
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Mycobacterium tuberculosis / drug effects*
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Plant Shoots / chemistry
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Pyrans / chemistry
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Pyrans / isolation & purification
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Pyrans / pharmacology*
Substances
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2,4',6'-trihydroxy-3'-prenylchalcone
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4',6',5''-trihydroxy-6'',6''-dimethyldihydropyrano(2'',3''-2',3') chalcone
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Antitubercular Agents
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Antiviral Agents
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Chalcones
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Pyrans
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Acetone