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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 1
1974 2
1975 6
1976 2
1977 1
1978 3
1979 4
1980 6
1981 3
1982 5
1983 2
1984 4
1985 6
1986 5
1987 7
1988 7
1989 7
1990 8
1991 19
1992 14
1993 16
1994 20
1995 18
1996 20
1997 21
1998 24
1999 35
2000 33
2001 31
2002 38
2003 28
2004 39
2005 48
2006 51
2007 36
2008 50
2009 54
2010 48
2011 57
2012 50
2013 49
2014 70
2015 72
2016 74
2017 66
2018 83
2019 71
2020 81
2021 93
2022 66
2023 67
2024 21

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1,551 results

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Page 1
Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning.
Horne RI, Andrzejewska EA, Alam P, Brotzakis ZF, Srivastava A, Aubert A, Nowinska M, Gregory RC, Staats R, Possenti A, Chia S, Sormanni P, Ghetti B, Caughey B, Knowles TPJ, Vendruscolo M. Horne RI, et al. Among authors: knowles tpj, vendruscolo m. Nat Chem Biol. 2024 Apr 17. doi: 10.1038/s41589-024-01580-x. Online ahead of print. Nat Chem Biol. 2024. PMID: 38632492
RASP: Optimal Single Puncta Detection in Complex Cellular Backgrounds.
Fu B, Brock EE, Andrews R, Breiter JC, Tian R, Toomey CE, Lachica J, Lashley T, Ryten M, Wood NW, Vendruscolo M, Gandhi S, Weiss LE, Beckwith JS, Lee SF. Fu B, et al. Among authors: vendruscolo m. J Phys Chem B. 2024 Apr 18;128(15):3585-3597. doi: 10.1021/acs.jpcb.4c00174. Epub 2024 Apr 9. J Phys Chem B. 2024. PMID: 38593280
Structure-Toxicity Relationship in Intermediate Fibrils from α-Synuclein Condensates.
Chen SW, Barritt JD, Cascella R, Bigi A, Cecchi C, Banchelli M, Gallo A, Jarvis JA, Chiti F, Dobson CM, Fusco G, De Simone A. Chen SW, et al. Among authors: dobson cm. J Am Chem Soc. 2024 Apr 17;146(15):10537-10549. doi: 10.1021/jacs.3c14703. Epub 2024 Apr 3. J Am Chem Soc. 2024. PMID: 38567991 Free PMC article.
Design of amyloidogenic peptide traps.
Sahtoe DD, Andrzejewska EA, Han HL, Rennella E, Schneider MM, Meisl G, Ahlrichs M, Decarreau J, Nguyen H, Kang A, Levine P, Lamb M, Li X, Bera AK, Kay LE, Knowles TPJ, Baker D. Sahtoe DD, et al. Among authors: knowles tpj. Nat Chem Biol. 2024 Mar 19. doi: 10.1038/s41589-024-01578-5. Online ahead of print. Nat Chem Biol. 2024. PMID: 38503834
A Relationship between the Structures and Neurotoxic Effects of Aβ Oligomers Stabilized by Different Metal Ions.
Chia S, Cataldi RL, Ruggeri FS, Limbocker R, Condado-Morales I, Pisani K, Possenti A, Linse S, Knowles TPJ, Habchi J, Mannini B, Vendruscolo M. Chia S, et al. Among authors: knowles tpj, linse s, vendruscolo m. ACS Chem Neurosci. 2024 Mar 20;15(6):1125-1134. doi: 10.1021/acschemneuro.3c00718. Epub 2024 Feb 28. ACS Chem Neurosci. 2024. PMID: 38416693 Free PMC article.
Self-replication of Aβ42 aggregates occurs on small and isolated fibril sites.
Curk S, Krausser J, Meisl G, Frenkel D, Linse S, Michaels TCT, Knowles TPJ, Šarić A. Curk S, et al. Among authors: knowles tpj, linse s. Proc Natl Acad Sci U S A. 2024 Feb 13;121(7):e2220075121. doi: 10.1073/pnas.2220075121. Epub 2024 Feb 9. Proc Natl Acad Sci U S A. 2024. PMID: 38335256 Free PMC article.
Selenium-silk microgels as antifungal and antibacterial agents.
Wiita EG, Toprakcioglu Z, Jayaram AK, Knowles TPJ. Wiita EG, et al. Among authors: knowles tpj. Nanoscale Horiz. 2024 Mar 25;9(4):609-619. doi: 10.1039/d3nh00385j. Nanoscale Horiz. 2024. PMID: 38288551 Free PMC article.
Microfluidic antibody profiling after repeated SARS-CoV-2 vaccination links antibody affinity and concentration to impaired immunity and variant escape in patients on anti-CD20 therapy.
Priddey A, Chen-Xu MXH, Cooper DJ, MacMillan S, Meisl G, Xu CK, Hosmillo M, Goodfellow IG, Kollyfas R, Doffinger R, Bradley JR, Mohorianu II, Jones R, Knowles TPJ, Smith R, Kosmoliaptsis V. Priddey A, et al. Among authors: knowles tpj. Front Immunol. 2024 Jan 8;14:1296148. doi: 10.3389/fimmu.2023.1296148. eCollection 2023. Front Immunol. 2024. PMID: 38259440 Free PMC article.
Nonspecificity fingerprints for clinical-stage antibodies in solution.
Herling TW, Invernizzi G, Ausserwöger H, Bjelke JR, Egebjerg T, Lund S, Lorenzen N, Knowles TPJ. Herling TW, et al. Among authors: knowles tpj. Proc Natl Acad Sci U S A. 2023 Dec 26;120(52):e2306700120. doi: 10.1073/pnas.2306700120. Epub 2023 Dec 18. Proc Natl Acad Sci U S A. 2023. PMID: 38109540
The role of phosphorylation in calmodulin-mediated gating of human AQP0.
Kreida S, Roche JV, Missel JW, Al-Jubair T, Hagströmer CJ, Wittenbecher V, Linse S, Gourdon P, Törnroth-Horsefield S. Kreida S, et al. Among authors: linse s. Biochem J. 2024 Jan 10;481(1):17-32. doi: 10.1042/BCJ20230158. Biochem J. 2024. PMID: 38032258 Free PMC article.
Multiplexed Digital Characterization of Misfolded Protein Oligomers via Solid-State Nanopores.
Sandler SE, Horne RI, Rocchetti S, Novak R, Hsu NS, Castellana Cruz M, Faidon Brotzakis Z, Gregory RC, Chia S, Bernardes GJL, Keyser UF, Vendruscolo M. Sandler SE, et al. Among authors: vendruscolo m. J Am Chem Soc. 2023 Nov 29;145(47):25776-25788. doi: 10.1021/jacs.3c09335. Epub 2023 Nov 16. J Am Chem Soc. 2023. PMID: 37972287 Free PMC article.
Effects of Processing-Induced Contamination on Organic Electronic Devices.
Simatos D, Jacobs IE, Dobryden I, Nguyen M, Savva A, Venkateshvaran D, Nikolka M, Charmet J, Spalek LJ, Gicevičius M, Zhang Y, Schweicher G, Howe DJ, Ursel S, Armitage J, Dimov IB, Kraft U, Zhang W, Alsufyani M, McCulloch I, Owens RM, Claesson PM, Knowles TPJ, Sirringhaus H. Simatos D, et al. Among authors: knowles tpj. Small Methods. 2023 Nov;7(11):e2300476. doi: 10.1002/smtd.202300476. Epub 2023 Sep 3. Small Methods. 2023. PMID: 37661594
Photo-Induced Cross-Linking of Unmodified α-Synuclein Oligomers.
Ortigosa-Pascual L, Leiding T, Linse S, Pálmadóttir T. Ortigosa-Pascual L, et al. Among authors: linse s. ACS Chem Neurosci. 2023 Sep 6;14(17):3192-3205. doi: 10.1021/acschemneuro.3c00326. Epub 2023 Aug 24. ACS Chem Neurosci. 2023. PMID: 37621159 Free PMC article.
On the micelle formation of DNAJB6b.
Carlsson A, Olsson U, Linse S. Carlsson A, et al. Among authors: linse s. QRB Discov. 2023 Aug 15;4:e6. doi: 10.1017/qrd.2023.4. eCollection 2023. QRB Discov. 2023. PMID: 37593255 Free PMC article.
The liquid-to-solid transition of FUS is promoted by the condensate surface.
Shen Y, Chen A, Wang W, Shen Y, Ruggeri FS, Aime S, Wang Z, Qamar S, Espinosa JR, Garaizar A, St George-Hyslop P, Collepardo-Guevara R, Weitz DA, Vigolo D, Knowles TPJ. Shen Y, et al. Among authors: knowles tpj. Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2301366120. doi: 10.1073/pnas.2301366120. Epub 2023 Aug 7. Proc Natl Acad Sci U S A. 2023. PMID: 37549257 Free PMC article.
Electrophysiological In Vitro Study of Long-Range Signal Transmission by Astrocytic Networks.
Hastings N, Yu YL, Huang B, Middya S, Inaoka M, Erkamp NA, Mason RJ, Carnicer-Lombarte A, Rahman S, Knowles TPJ, Bance M, Malliaras GG, Kotter MRN. Hastings N, et al. Among authors: knowles tpj. Adv Sci (Weinh). 2023 Oct;10(29):e2301756. doi: 10.1002/advs.202301756. Epub 2023 Jul 23. Adv Sci (Weinh). 2023. PMID: 37485646 Free PMC article.
Quantitative Attribution of the Protective Effects of Aminosterols against Protein Aggregates to Their Chemical Structures and Ability to Modulate Biological Membranes.
Errico S, Lucchesi G, Odino D, Osman EY, Cascella R, Neri L, Capitini C, Calamai M, Bemporad F, Cecchi C, Kinney WA, Barbut D, Relini A, Canale C, Caminati G, Limbocker R, Vendruscolo M, Zasloff M, Chiti F. Errico S, et al. Among authors: vendruscolo m. J Med Chem. 2023 Jul 27;66(14):9519-9536. doi: 10.1021/acs.jmedchem.3c00182. Epub 2023 Jul 11. J Med Chem. 2023. PMID: 37433124 Free PMC article.
Amyloids and protein aggregation.
Linse S, Knowles T. Linse S, et al. Chem Sci. 2023 Jun 6;14(24):6491-6492. doi: 10.1039/d2sc90225g. eCollection 2023 Jun 21. Chem Sci. 2023. PMID: 37350828 Free PMC article.
Positional influence on cellular transcriptional identity revealed through spatially segmented single-cell transcriptomics.
Morse DB, Michalowski AM, Ceribelli M, De Jonghe J, Vias M, Riley D, Davies-Hill T, Voss T, Pittaluga S, Muus C, Liu J, Boyle S, Weitz DA, Brenton JD, Buenrostro JD, Knowles TPJ, Thomas CJ. Morse DB, et al. Among authors: knowles tpj. Cell Syst. 2023 Jun 21;14(6):464-481.e7. doi: 10.1016/j.cels.2023.05.003. Cell Syst. 2023. PMID: 37348462 Free PMC article.
Formation of Protein Nanoparticles in Microdroplet Flow Reactors.
Zhang Q, Toprakcioglu Z, Jayaram AK, Guo G, Wang X, Knowles TPJ. Zhang Q, et al. Among authors: knowles tpj. ACS Nano. 2023 Jun 27;17(12):11335-11344. doi: 10.1021/acsnano.3c00107. Epub 2023 Jun 12. ACS Nano. 2023. PMID: 37306477 Free PMC article.
De Novo Human Angiotensin-Converting Enzyme 2 Decoy NL-CVX1 Protects Mice From Severe Disease After Severe Acute Respiratory Syndrome Coronavirus 2 Infection.
Rebelo M, Tang C, Coelho AR, Labão-Almeida C, Schneider MM, Tatalick L, Ruivo P, de Miranda MP, Gomes A, Carvalho T, Walker MJ, Ausserwoeger H, Pedro Simas J, Veldhoen M, Knowles TPJ, Silva DA, Shoultz D, Bernardes GJL. Rebelo M, et al. Among authors: knowles tpj. J Infect Dis. 2023 Sep 15;228(6):723-733. doi: 10.1093/infdis/jiad135. J Infect Dis. 2023. PMID: 37279654 Free PMC article.
Case report of a patient with unclassified tauopathy with molecular and neuropathological features of both progressive supranuclear palsy and corticobasal degeneration.
Koga S, Metrick MA 2nd, Golbe LI, Santambrogio A, Kim M, Soto-Beasley AI, Walton RL, Baker MC, De Castro CF, DeTure M, Russell D, Navia BA, Sandiego C, Ross OA, Vendruscolo M, Caughey B, Dickson DW. Koga S, et al. Among authors: vendruscolo m. Acta Neuropathol Commun. 2023 Jun 1;11(1):88. doi: 10.1186/s40478-023-01584-z. Acta Neuropathol Commun. 2023. PMID: 37264457 Free PMC article.
Theoretical and Data-Driven Approaches for Biomolecular Condensates.
Saar KL, Qian D, Good LL, Morgunov AS, Collepardo-Guevara R, Best RB, Knowles TPJ. Saar KL, et al. Among authors: knowles tpj. Chem Rev. 2023 Jul 26;123(14):8988-9009. doi: 10.1021/acs.chemrev.2c00586. Epub 2023 May 12. Chem Rev. 2023. PMID: 37171907 Free PMC article. Review.
Non-specificity as the sticky problem in therapeutic antibody development.
Ausserwöger H, Schneider MM, Herling TW, Arosio P, Invernizzi G, Knowles TPJ, Lorenzen N. Ausserwöger H, et al. Among authors: knowles tpj. Nat Rev Chem. 2022 Dec;6(12):844-861. doi: 10.1038/s41570-022-00438-x. Epub 2022 Nov 14. Nat Rev Chem. 2022. PMID: 37117703 Review.
Surface patches induce nonspecific binding and phase separation of antibodies.
Ausserwöger H, Krainer G, Welsh TJ, Thorsteinson N, de Csilléry E, Sneideris T, Schneider MM, Egebjerg T, Invernizzi G, Herling TW, Lorenzen N, Knowles TPJ. Ausserwöger H, et al. Among authors: knowles tpj. Proc Natl Acad Sci U S A. 2023 Apr 11;120(15):e2210332120. doi: 10.1073/pnas.2210332120. Epub 2023 Apr 3. Proc Natl Acad Sci U S A. 2023. PMID: 37011217 Free PMC article.
The amyloid-β pathway in Alzheimer's disease: a plain language summary.
Hampel H, Hu Y, Hardy J, Blennow K, Chen C, Perry G, Kim SH, Villemagne VL, Aisen P, Vendruscolo M, Iwatsubo T, Masters CL, Cho M, Lannfelt L, Cummings JL, Vergallo A. Hampel H, et al. Among authors: vendruscolo m. Neurodegener Dis Manag. 2023 Jun;13(3):141-149. doi: 10.2217/nmt-2022-0037. Epub 2023 Mar 30. Neurodegener Dis Manag. 2023. PMID: 36994753 Free PMC article. Review.
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes.
Nixon-Abell J, Ruggeri FS, Qamar S, Herling TW, Czekalska MA, Shen Y, Wang G, King C, Fernandopulle MS, Sneideris T, Watson JL, Pillai VVS, Meadows W, Henderson JW, Chambers JE, Wagstaff JL, Williams SH, Coyle H, Lu Y, Zhang S, Marciniak SJ, Freund SMV, Derivery E, Ward ME, Vendruscolo M, Knowles TPJ, St George-Hyslop P. Nixon-Abell J, et al. Among authors: knowles tpj, vendruscolo m. bioRxiv [Preprint]. 2023 Mar 24:2023.03.22.533832. doi: 10.1101/2023.03.22.533832. bioRxiv. 2023. PMID: 36993242 Free PMC article. Preprint.
Exploration and Exploitation Approaches Based on Generative Machine Learning to Identify Potent Small Molecule Inhibitors of α-Synuclein Secondary Nucleation.
Horne RI, Murtada MH, Huo D, Brotzakis ZF, Gregory RC, Possenti A, Chia S, Vendruscolo M. Horne RI, et al. Among authors: vendruscolo m. J Chem Theory Comput. 2023 Jul 25;19(14):4701-4710. doi: 10.1021/acs.jctc.2c01303. Epub 2023 Mar 20. J Chem Theory Comput. 2023. PMID: 36939645 Free PMC article.
Microfluidic antibody affinity profiling of alloantibody-HLA interactions in human serum.
Schneider MM, Scheidt T, Priddey AJ, Xu CK, Hu M, Meisl G, Devenish SRA, Dobson CM, Kosmoliaptsis V, Knowles TPJ. Schneider MM, et al. Among authors: knowles tpj, dobson cm. Biosens Bioelectron. 2023 May 15;228:115196. doi: 10.1016/j.bios.2023.115196. Epub 2023 Mar 5. Biosens Bioelectron. 2023. PMID: 36921387 Free article.
Extracellular protein homeostasis in neurodegenerative diseases.
Wilson MR, Satapathy S, Vendruscolo M. Wilson MR, et al. Among authors: vendruscolo m. Nat Rev Neurol. 2023 Apr;19(4):235-245. doi: 10.1038/s41582-023-00786-2. Epub 2023 Feb 24. Nat Rev Neurol. 2023. PMID: 36828943 Review.
Single-Molecule Sizing through Nanocavity Confinement.
Jacquat RPB, Krainer G, Peter QAE, Babar AN, Vanderpoorten O, Xu CK, Welsh TJ, Kaminski CF, Keyser UF, Baumberg JJ, Knowles TPJ. Jacquat RPB, et al. Among authors: knowles tpj. Nano Lett. 2023 Mar 8;23(5):1629-1636. doi: 10.1021/acs.nanolett.1c04830. Epub 2023 Feb 24. Nano Lett. 2023. PMID: 36826991 Free PMC article.
Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes.
Bhardwaj T, Gadhave K, Kapuganti SK, Kumar P, Brotzakis ZF, Saumya KU, Nayak N, Kumar A, Joshi R, Mukherjee B, Bhardwaj A, Thakur KG, Garg N, Vendruscolo M, Giri R. Bhardwaj T, et al. Among authors: vendruscolo m. Nat Commun. 2023 Feb 20;14(1):945. doi: 10.1038/s41467-023-36234-4. Nat Commun. 2023. PMID: 36806058 Free PMC article.
Selenium Silk Nanostructured Films with Antifungal and Antibacterial Activity.
Toprakcioglu Z, Wiita EG, Jayaram AK, Gregory RC, Knowles TPJ. Toprakcioglu Z, et al. Among authors: knowles tpj. ACS Appl Mater Interfaces. 2023 Mar 1;15(8):10452-10463. doi: 10.1021/acsami.2c21013. Epub 2023 Feb 20. ACS Appl Mater Interfaces. 2023. PMID: 36802477 Free PMC article.
Spontaneous nucleation and fast aggregate-dependent proliferation of α-synuclein aggregates within liquid condensates at neutral pH.
Dada ST, Hardenberg MC, Toprakcioglu Z, Mrugalla LK, Cali MP, McKeon MO, Klimont E, Michaels TCT, Knowles TPJ, Vendruscolo M. Dada ST, et al. Among authors: knowles tpj, vendruscolo m. Proc Natl Acad Sci U S A. 2023 Feb 28;120(9):e2208792120. doi: 10.1073/pnas.2208792120. Epub 2023 Feb 21. Proc Natl Acad Sci U S A. 2023. PMID: 36802433 Free PMC article.
Correction to: Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease.
Boza-Serrano A, Ruiz R, Sanchez-Varo R, García-Revilla J, Yang Y, Jimenez-Ferrer I, Paulus A, Wennström M, Vilalta A, Allendorf D, Davila JC, Stegmayr J, Jiménez S, Roca-Ceballos MA, Navarro-Garrido V, Swanberg M, Hsieh CL, Real LM, Englund E, Linse S, Leffler H, Nilsson UJ, Brown GC, Gutierrez A, Vitorica J, Venero JL, Deierborg T. Boza-Serrano A, et al. Among authors: linse s. Acta Neuropathol. 2023 Apr;145(4):509-510. doi: 10.1007/s00401-023-02549-1. Acta Neuropathol. 2023. PMID: 36790609 Free PMC article. No abstract available.
Direct digital sensing of protein biomarkers in solution.
Krainer G, Saar KL, Arter WE, Welsh TJ, Czekalska MA, Jacquat RPB, Peter Q, Traberg WC, Pujari A, Jayaram AK, Challa P, Taylor CG, van der Linden LM, Franzmann T, Owens RM, Alberti S, Klenerman D, Knowles TPJ. Krainer G, et al. Among authors: knowles tpj. Nat Commun. 2023 Feb 6;14(1):653. doi: 10.1038/s41467-023-35792-x. Nat Commun. 2023. PMID: 36746944 Free PMC article.
Enhanced surface nanoanalytics of transient biomolecular processes.
Miller A, Chia S, Toprakcioglu Z, Hakala T, Schmid R, Feng Y, Kartanas T, Kamada A, Vendruscolo M, Ruggeri FS, Knowles TPJ. Miller A, et al. Among authors: knowles tpj, vendruscolo m. Sci Adv. 2023 Jan 13;9(2):eabq3151. doi: 10.1126/sciadv.abq3151. Epub 2023 Jan 13. Sci Adv. 2023. PMID: 36638180 Free PMC article.
Continuous population-level monitoring of SARS-CoV-2 seroprevalence in a large European metropolitan region.
Emmenegger M, De Cecco E, Lamparter D, Jacquat RPB, Riou J, Menges D, Ballouz T, Ebner D, Schneider MM, Morales IC, Doğançay B, Guo J, Wiedmer A, Domange J, Imeri M, Moos R, Zografou C, Batkitar L, Madrigal L, Schneider D, Trevisan C, Gonzalez-Guerra A, Carrella A, Dubach IL, Xu CK, Meisl G, Kosmoliaptsis V, Malinauskas T, Burgess-Brown N, Owens R, Hatch S, Mongkolsapaya J, Screaton GR, Schubert K, Huck JD, Liu F, Pojer F, Lau K, Hacker D, Probst-Müller E, Cervia C, Nilsson J, Boyman O, Saleh L, Spanaus K, von Eckardstein A, Schaer DJ, Ban N, Tsai CJ, Marino J, Schertler GFX, Ebert N, Thiel V, Gottschalk J, Frey BM, Reimann RR, Hornemann S, Ring AM, Knowles TPJ, Puhan MA, Althaus CL, Xenarios I, Stuart DI, Aguzzi A. Emmenegger M, et al. Among authors: knowles tpj. iScience. 2023 Feb 17;26(2):105928. doi: 10.1016/j.isci.2023.105928. Epub 2023 Jan 4. iScience. 2023. PMID: 36619367 Free PMC article.
A Kinetic Map of the Influence of Biomimetic Lipid Model Membranes on Aβ42 Aggregation.
Baumann KN, Šneiderienė G, Sanguanini M, Schneider M, Rimon O, González Díaz A, Greer H, Thacker D, Linse S, Knowles TPJ, Vendruscolo M. Baumann KN, et al. Among authors: knowles tpj, linse s, vendruscolo m. ACS Chem Neurosci. 2023 Jan 18;14(2):323-329. doi: 10.1021/acschemneuro.2c00765. Epub 2022 Dec 27. ACS Chem Neurosci. 2023. PMID: 36574473 Free PMC article.
An antibody scanning method for the detection of α-synuclein oligomers in the serum of Parkinson's disease patients.
Kulenkampff K, Emin D, Staats R, Zhang YP, Sakhnini L, Kouli A, Rimon O, Lobanova E, Williams-Gray CH, Aprile FA, Sormanni P, Klenerman D, Vendruscolo M. Kulenkampff K, et al. Among authors: vendruscolo m. Chem Sci. 2022 Sep 22;13(46):13815-13828. doi: 10.1039/d2sc00066k. eCollection 2022 Nov 30. Chem Sci. 2022. PMID: 36544716 Free PMC article.
Biomolecular condensate phase diagrams with a combinatorial microdroplet platform.
Arter WE, Qi R, Erkamp NA, Krainer G, Didi K, Welsh TJ, Acker J, Nixon-Abell J, Qamar S, Guillén-Boixet J, Franzmann TM, Kuster D, Hyman AA, Borodavka A, George-Hyslop PS, Alberti S, Knowles TPJ. Arter WE, et al. Among authors: knowles tpj. Nat Commun. 2022 Dec 21;13(1):7845. doi: 10.1038/s41467-022-35265-7. Nat Commun. 2022. PMID: 36543777 Free PMC article.
Perphenazine-Macrocycle Conjugates Rapidly Sequester the Aβ42 Monomer and Prevent Formation of Toxic Oligomers and Amyloid.
Ball SR, Adamson JSP, Sullivan MA, Zimmermann MR, Lo V, Sanz-Hernandez M, Jiang X, Kwan AH, McKenzie ADJ, Werry EL, Knowles TPJ, Kassiou M, Meisl G, Todd MH, Rutledge PJ, Sunde M. Ball SR, et al. Among authors: knowles tpj. ACS Chem Neurosci. 2023 Jan 4;14(1):87-98. doi: 10.1021/acschemneuro.2c00498. Epub 2022 Dec 21. ACS Chem Neurosci. 2023. PMID: 36542544 Free PMC article.
EGCG inactivates a pore-forming toxin by promoting its oligomerization and decreasing its solvent-exposed hydrophobicity.
Gabriel JM, Tan T, Rinauro DJ, Hsu CM, Buettner CJ, Gilmer M, Kaur A, McKenzie TL, Park M, Cohen S, Errico S, Wright AK, Chiti F, Vendruscolo M, Limbocker R. Gabriel JM, et al. Among authors: vendruscolo m. Chem Biol Interact. 2023 Feb 1;371:110307. doi: 10.1016/j.cbi.2022.110307. Epub 2022 Dec 17. Chem Biol Interact. 2023. PMID: 36535315 Free article.
Structure-Based Discovery of Small-Molecule Inhibitors of the Autocatalytic Proliferation of α-Synuclein Aggregates.
Chia S, Faidon Brotzakis Z, Horne RI, Possenti A, Mannini B, Cataldi R, Nowinska M, Staats R, Linse S, Knowles TPJ, Habchi J, Vendruscolo M. Chia S, et al. Among authors: knowles tpj, linse s, vendruscolo m. Mol Pharm. 2023 Jan 2;20(1):183-193. doi: 10.1021/acs.molpharmaceut.2c00548. Epub 2022 Nov 14. Mol Pharm. 2023. PMID: 36374974 Free PMC article.
Fragment-based computational design of antibodies targeting structured epitopes.
Aguilar Rangel M, Bedwell A, Costanzi E, Taylor RJ, Russo R, Bernardes GJL, Ricagno S, Frydman J, Vendruscolo M, Sormanni P. Aguilar Rangel M, et al. Among authors: vendruscolo m. Sci Adv. 2022 Nov 11;8(45):eabp9540. doi: 10.1126/sciadv.abp9540. Epub 2022 Nov 11. Sci Adv. 2022. PMID: 36367941 Free PMC article.
The Chromatin Regulator HMGA1a Undergoes Phase Separation in the Nucleus.
Zhu H, Narita M, Joseph JA, Krainer G, Arter WE, Olan I, Saar KL, Ermann N, Espinosa JR, Shen Y, Kuri MA, Qi R, Welsh TJ, Collepardo-Guevara R, Narita M, Knowles TPJ. Zhu H, et al. Among authors: knowles tpj. Chembiochem. 2023 Jan 3;24(1):e202200450. doi: 10.1002/cbic.202200450. Epub 2022 Nov 30. Chembiochem. 2023. PMID: 36336658 Free PMC article.
Microscale Diffusiophoresis of Proteins.
Peter QAE, Jacquat RPB, Herling TW, Challa PK, Kartanas T, Knowles TPJ. Peter QAE, et al. Among authors: knowles tpj. J Phys Chem B. 2022 Nov 10;126(44):8913-8920. doi: 10.1021/acs.jpcb.2c04029. Epub 2022 Oct 28. J Phys Chem B. 2022. PMID: 36306420 Free PMC article.
Characterization of full-length p53 aggregates and their kinetics of formation.
Julian L, Sang JC, Wu Y, Meisl G, Brelstaff JH, Miller A, Cheetham MR, Vendruscolo M, Knowles TPJ, Ruggeri FS, Bryant C, Ros S, Brindle KM, Klenerman D. Julian L, et al. Among authors: knowles tpj, vendruscolo m. Biophys J. 2022 Nov 15;121(22):4280-4298. doi: 10.1016/j.bpj.2022.10.013. Epub 2022 Oct 13. Biophys J. 2022. PMID: 36230002 Free PMC article.
Influence of denaturants on amyloid β42 aggregation kinetics.
Weiffert T, Meisl G, Curk S, Cukalevski R, Šarić A, Knowles TPJ, Linse S. Weiffert T, et al. Among authors: knowles tpj, linse s. Front Neurosci. 2022 Sep 20;16:943355. doi: 10.3389/fnins.2022.943355. eCollection 2022. Front Neurosci. 2022. PMID: 36203800 Free PMC article.
Small soluble α-synuclein aggregates are the toxic species in Parkinson's disease.
Emin D, Zhang YP, Lobanova E, Miller A, Li X, Xia Z, Dakin H, Sideris DI, Lam JYL, Ranasinghe RT, Kouli A, Zhao Y, De S, Knowles TPJ, Vendruscolo M, Ruggeri FS, Aigbirhio FI, Williams-Gray CH, Klenerman D. Emin D, et al. Among authors: knowles tpj, vendruscolo m. Nat Commun. 2022 Sep 20;13(1):5512. doi: 10.1038/s41467-022-33252-6. Nat Commun. 2022. PMID: 36127374 Free PMC article.
Analytical Solution to the Flory-Huggins Model.
Qian D, Michaels TCT, Knowles TPJ. Qian D, et al. Among authors: knowles tpj. J Phys Chem Lett. 2022 Aug 25;13(33):7853-7860. doi: 10.1021/acs.jpclett.2c01986. Epub 2022 Aug 17. J Phys Chem Lett. 2022. PMID: 35977086 Free PMC article.
On the Aggregation of Apolipoprotein A-I.
Frankel R, Sparr E, Linse S. Frankel R, et al. Among authors: linse s. Int J Mol Sci. 2022 Aug 7;23(15):8780. doi: 10.3390/ijms23158780. Int J Mol Sci. 2022. PMID: 35955915 Free PMC article.
α-Synuclein Interaction with Lipid Bilayer Discs.
Dubackic M, Liu Y, Kelley EG, Hetherington C, Haertlein M, Devos JM, Linse S, Sparr E, Olsson U. Dubackic M, et al. Among authors: linse s. Langmuir. 2022 Aug 23;38(33):10216-10224. doi: 10.1021/acs.langmuir.2c01368. Epub 2022 Aug 11. Langmuir. 2022. PMID: 35952001 Free PMC article.
N-Terminal Acetylation of α-Synuclein Slows down Its Aggregation Process and Alters the Morphology of the Resulting Aggregates.
Bell R, Thrush RJ, Castellana-Cruz M, Oeller M, Staats R, Nene A, Flagmeier P, Xu CK, Satapathy S, Galvagnion C, Wilson MR, Dobson CM, Kumita JR, Vendruscolo M. Bell R, et al. Among authors: dobson cm, vendruscolo m. Biochemistry. 2022 Sep 6;61(17):1743-1756. doi: 10.1021/acs.biochem.2c00104. Epub 2022 Aug 9. Biochemistry. 2022. PMID: 35944093 Free PMC article.
Adsorption free energy predicts amyloid protein nucleation rates.
Toprakcioglu Z, Kamada A, Michaels TCT, Xie M, Krausser J, Wei J, Saric A, Vendruscolo M, Knowles TPJ. Toprakcioglu Z, et al. Among authors: knowles tpj, vendruscolo m. Proc Natl Acad Sci U S A. 2022 Aug 2;119(31):e2109718119. doi: 10.1073/pnas.2109718119. Epub 2022 Jul 28. Proc Natl Acad Sci U S A. 2022. PMID: 35901206 Free PMC article.
Both COVID-19 infection and vaccination induce high-affinity cross-clade responses to SARS-CoV-2 variants.
Emmenegger M, Fiedler S, Brugger SD, Devenish SRA, Morgunov AS, Ilsley A, Ricci F, Malik AY, Scheier T, Batkitar L, Madrigal L, Rossi M, Meisl G, Lynn AK, Saleh L, von Eckardstein A, Knowles TPJ, Aguzzi A. Emmenegger M, et al. Among authors: knowles tpj. iScience. 2022 Aug 19;25(8):104766. doi: 10.1016/j.isci.2022.104766. Epub 2022 Jul 16. iScience. 2022. PMID: 35875683 Free PMC article.
Correlation between the binding affinity and the conformational entropy of nanobody SARS-CoV-2 spike protein complexes.
Mikolajek H, Weckener M, Brotzakis ZF, Huo J, Dalietou EV, Le Bas A, Sormanni P, Harrison PJ, Ward PN, Truong S, Moynie L, Clare DK, Dumoux M, Dormon J, Norman C, Hussain N, Vogirala V, Owens RJ, Vendruscolo M, Naismith JH. Mikolajek H, et al. Among authors: vendruscolo m. Proc Natl Acad Sci U S A. 2022 Aug 2;119(31):e2205412119. doi: 10.1073/pnas.2205412119. Epub 2022 Jul 15. Proc Natl Acad Sci U S A. 2022. PMID: 35858383 Free PMC article.
DNA-Liposome Hybrid Carriers for Triggered Cargo Release.
Baumann KN, Schröder T, Ciryam PS, Morzy D, Tinnefeld P, Knowles TPJ, Hernández-Ainsa S. Baumann KN, et al. Among authors: knowles tpj. ACS Appl Bio Mater. 2022 Aug 15;5(8):3713-3721. doi: 10.1021/acsabm.2c00225. Epub 2022 Jul 15. ACS Appl Bio Mater. 2022. PMID: 35838663 Free PMC article.
Structure-specific amyloid precipitation in biofluids.
Rodrigues M, Bhattacharjee P, Brinkmalm A, Do DT, Pearson CM, De S, Ponjavic A, Varela JA, Kulenkampff K, Baudrexel I, Emin D, Ruggeri FS, Lee JE, Carr AR, Knowles TPJ, Zetterberg H, Snaddon TN, Gandhi S, Lee SF, Klenerman D. Rodrigues M, et al. Among authors: knowles tpj. Nat Chem. 2022 Sep;14(9):1045-1053. doi: 10.1038/s41557-022-00976-3. Epub 2022 Jul 7. Nat Chem. 2022. PMID: 35798951 Free article.
Recent Advances in Microgels: From Biomolecules to Functionality.
Xu Y, Zhu H, Denduluri A, Ou Y, Erkamp NA, Qi R, Shen Y, Knowles TPJ. Xu Y, et al. Among authors: knowles tpj. Small. 2022 Aug;18(34):e2200180. doi: 10.1002/smll.202200180. Epub 2022 Jul 5. Small. 2022. PMID: 35790106 Review.
Phase-separating RNA-binding proteins form heterogeneous distributions of clusters in subsaturated solutions.
Kar M, Dar F, Welsh TJ, Vogel LT, Kühnemuth R, Majumdar A, Krainer G, Franzmann TM, Alberti S, Seidel CAM, Knowles TPJ, Hyman AA, Pappu RV. Kar M, et al. Among authors: knowles tpj. Proc Natl Acad Sci U S A. 2022 Jul 12;119(28):e2202222119. doi: 10.1073/pnas.2202222119. Epub 2022 Jul 5. Proc Natl Acad Sci U S A. 2022. PMID: 35787038 Free PMC article.
A Brain-Permeable Aminosterol Regulates Cell Membranes to Mitigate the Toxicity of Diverse Pore-Forming Agents.
Kreiser RP, Wright AK, Sasser LR, Rinauro DJ, Gabriel JM, Hsu CM, Hurtado JA, McKenzie TL, Errico S, Albright JA, Richardson L, Jaffett VA, Riegner DE, Nguyen LT, LeForte K, Zasloff M, Hollows JE, Chiti F, Vendruscolo M, Limbocker R. Kreiser RP, et al. Among authors: vendruscolo m. ACS Chem Neurosci. 2022 Apr 20;13(8):1219-1231. doi: 10.1021/acschemneuro.1c00840. Epub 2022 Apr 11. ACS Chem Neurosci. 2022. PMID: 35404569 Free PMC article.
Microfluidic Antibody Affinity Profiling Reveals the Role of Memory Reactivation and Cross-Reactivity in the Defense Against SARS-CoV-2.
Denninger V, Xu CK, Meisl G, Morgunov AS, Fiedler S, Ilsley A, Emmenegger M, Malik AY, Piziorska MA, Schneider MM, Devenish SRA, Kosmoliaptsis V, Aguzzi A, Fiegler H, Knowles TPJ. Denninger V, et al. Among authors: knowles tpj. ACS Infect Dis. 2022 Apr 8;8(4):790-799. doi: 10.1021/acsinfecdis.1c00486. Epub 2022 Mar 30. ACS Infect Dis. 2022. PMID: 35352558
Surface Electrostatics Govern the Emulsion Stability of Biomolecular Condensates.
Welsh TJ, Krainer G, Espinosa JR, Joseph JA, Sridhar A, Jahnel M, Arter WE, Saar KL, Alberti S, Collepardo-Guevara R, Knowles TPJ. Welsh TJ, et al. Among authors: knowles tpj. Nano Lett. 2022 Jan 26;22(2):612-621. doi: 10.1021/acs.nanolett.1c03138. Epub 2022 Jan 10. Nano Lett. 2022. PMID: 35001622
1H detection and dynamic nuclear polarization-enhanced NMR of Aβ1-42 fibrils.
Bahri S, Silvers R, Michael B, Jaudzems K, Lalli D, Casano G, Ouari O, Lesage A, Pintacuda G, Linse S, Griffin RG. Bahri S, et al. Among authors: linse s. Proc Natl Acad Sci U S A. 2022 Jan 4;119(1):e2114413119. doi: 10.1073/pnas.2114413119. Proc Natl Acad Sci U S A. 2022. PMID: 34969859 Free PMC article.
Identification of a Thyroid Hormone Derivative as a Pleiotropic Agent for the Treatment of Alzheimer's Disease.
Runfola M, Perni M, Yang X, Marchese M, Bacci A, Mero S, Santorelli FM, Polini B, Chiellini G, Giuliani D, Vilella A, Bodria M, Daini E, Vandini E, Rudge S, Gul S, Wakelam MOJ, Vendruscolo M, Rapposelli S. Runfola M, et al. Among authors: vendruscolo m. Pharmaceuticals (Basel). 2021 Dec 19;14(12):1330. doi: 10.3390/ph14121330. Pharmaceuticals (Basel). 2021. PMID: 34959730 Free PMC article.
Common sequence motifs of nascent chains engage the ribosome surface and trigger factor.
Deckert A, Cassaignau AME, Wang X, Włodarski T, Chan SHS, Waudby CA, Kirkpatrick JP, Vendruscolo M, Cabrita LD, Christodoulou J. Deckert A, et al. Among authors: vendruscolo m. Proc Natl Acad Sci U S A. 2021 Dec 28;118(52):e2103015118. doi: 10.1073/pnas.2103015118. Proc Natl Acad Sci U S A. 2021. PMID: 34930833 Free PMC article.
Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma.
Schneider MM, Emmenegger M, Xu CK, Condado Morales I, Meisl G, Turelli P, Zografou C, Zimmermann MR, Frey BM, Fiedler S, Denninger V, Jacquat RP, Madrigal L, Ilsley A, Kosmoliaptsis V, Fiegler H, Trono D, Knowles TP, Aguzzi A. Schneider MM, et al. Among authors: knowles tp. Life Sci Alliance. 2021 Nov 30;5(2):e202101270. doi: 10.26508/lsa.202101270. Print 2022 Feb. Life Sci Alliance. 2021. PMID: 34848436 Free PMC article.
Amyloid β 42 fibril structure based on small-angle scattering.
Lattanzi V, André I, Gasser U, Dubackic M, Olsson U, Linse S. Lattanzi V, et al. Among authors: linse s. Proc Natl Acad Sci U S A. 2021 Nov 30;118(48):e2112783118. doi: 10.1073/pnas.2112783118. Proc Natl Acad Sci U S A. 2021. PMID: 34815346 Free PMC article.
Surface-Catalyzed Secondary Nucleation Dominates the Generation of Toxic IAPP Aggregates.
Rodriguez Camargo DC, Chia S, Menzies J, Mannini B, Meisl G, Lundqvist M, Pohl C, Bernfur K, Lattanzi V, Habchi J, Cohen SI, Knowles TPJ, Vendruscolo M, Linse S. Rodriguez Camargo DC, et al. Among authors: knowles tpj, linse s, vendruscolo m. Front Mol Biosci. 2021 Nov 1;8:757425. doi: 10.3389/fmolb.2021.757425. eCollection 2021. Front Mol Biosci. 2021. PMID: 34790701 Free PMC article.
Proliferation of Tau 304-380 Fragment Aggregates through Autocatalytic Secondary Nucleation.
Rodriguez Camargo DC, Sileikis E, Chia S, Axell E, Bernfur K, Cataldi RL, Cohen SIA, Meisl G, Habchi J, Knowles TPJ, Vendruscolo M, Linse S. Rodriguez Camargo DC, et al. Among authors: knowles tpj, linse s, vendruscolo m. ACS Chem Neurosci. 2021 Dec 1;12(23):4406-4415. doi: 10.1021/acschemneuro.1c00454. Epub 2021 Nov 16. ACS Chem Neurosci. 2021. PMID: 34783519 Free PMC article.
On the Cluster Formation of α-Synuclein Fibrils.
Dubackic M, Idini I, Lattanzi V, Liu Y, Martel A, Terry A, Haertlein M, Devos JM, Jackson A, Sparr E, Linse S, Olsson U. Dubackic M, et al. Among authors: linse s. Front Mol Biosci. 2021 Oct 19;8:768004. doi: 10.3389/fmolb.2021.768004. eCollection 2021. Front Mol Biosci. 2021. PMID: 34738016 Free PMC article.
In vivo rate-determining steps of tau seed accumulation in Alzheimer's disease.
Meisl G, Hidari E, Allinson K, Rittman T, DeVos SL, Sanchez JS, Xu CK, Duff KE, Johnson KA, Rowe JB, Hyman BT, Knowles TPJ, Klenerman D. Meisl G, et al. Among authors: knowles tpj. Sci Adv. 2021 Oct 29;7(44):eabh1448. doi: 10.1126/sciadv.abh1448. Epub 2021 Oct 29. Sci Adv. 2021. PMID: 34714685 Free PMC article.
The Hsc70 disaggregation machinery removes monomer units directly from α-synuclein fibril ends.
Schneider MM, Gautam S, Herling TW, Andrzejewska E, Krainer G, Miller AM, Trinkaus VA, Peter QAE, Ruggeri FS, Vendruscolo M, Bracher A, Dobson CM, Hartl FU, Knowles TPJ. Schneider MM, et al. Among authors: knowles tpj, dobson cm, vendruscolo m. Nat Commun. 2021 Oct 14;12(1):5999. doi: 10.1038/s41467-021-25966-w. Nat Commun. 2021. PMID: 34650037 Free PMC article.
Sequential storage and release of microdroplets.
Toprakcioglu Z, Knowles TPJ. Toprakcioglu Z, et al. Among authors: knowles tpj. Microsyst Nanoeng. 2021 Sep 29;7:76. doi: 10.1038/s41378-021-00303-9. eCollection 2021. Microsyst Nanoeng. 2021. PMID: 34631144 Free PMC article.
The cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation.
Pras A, Houben B, Aprile FA, Seinstra R, Gallardo R, Janssen L, Hogewerf W, Gallrein C, De Vleeschouwer M, Mata-Cabana A, Koopman M, Stroo E, de Vries M, Louise Edwards S, Kirstein J, Vendruscolo M, Falsone SF, Rousseau F, Schymkowitz J, Nollen EAA. Pras A, et al. Among authors: vendruscolo m. EMBO J. 2021 Nov 2;40(21):e107568. doi: 10.15252/embj.2020107568. Epub 2021 Oct 7. EMBO J. 2021. PMID: 34617299 Free PMC article.
The binding of the small heat-shock protein αB-crystallin to fibrils of α-synuclein is driven by entropic forces.
Scheidt T, Carozza JA, Kolbe CC, Aprile FA, Tkachenko O, Bellaiche MMJ, Meisl G, Peter QAE, Herling TW, Ness S, Castellana-Cruz M, Benesch JLP, Vendruscolo M, Dobson CM, Arosio P, Knowles TPJ. Scheidt T, et al. Among authors: knowles tpj, dobson cm, vendruscolo m. Proc Natl Acad Sci U S A. 2021 Sep 21;118(38):e2108790118. doi: 10.1073/pnas.2108790118. Proc Natl Acad Sci U S A. 2021. PMID: 34518228 Free PMC article.
New Frontiers for Machine Learning in Protein Science.
Morgunov AS, Saar KL, Vendruscolo M, Knowles TPJ. Morgunov AS, et al. Among authors: knowles tpj, vendruscolo m. J Mol Biol. 2021 Oct 1;433(20):167232. doi: 10.1016/j.jmb.2021.167232. Epub 2021 Sep 6. J Mol Biol. 2021. PMID: 34499920
The Amyloid-β Pathway in Alzheimer's Disease.
Hampel H, Hardy J, Blennow K, Chen C, Perry G, Kim SH, Villemagne VL, Aisen P, Vendruscolo M, Iwatsubo T, Masters CL, Cho M, Lannfelt L, Cummings JL, Vergallo A. Hampel H, et al. Among authors: vendruscolo m. Mol Psychiatry. 2021 Oct;26(10):5481-5503. doi: 10.1038/s41380-021-01249-0. Epub 2021 Aug 30. Mol Psychiatry. 2021. PMID: 34456336 Free PMC article. Review.
Soluble amyloid beta-containing aggregates are present throughout the brain at early stages of Alzheimer's disease.
Sideris DI, Danial JSH, Emin D, Ruggeri FS, Xia Z, Zhang YP, Lobanova E, Dakin H, De S, Miller A, Sang JC, Knowles TPJ, Vendruscolo M, Fraser G, Crowther D, Klenerman D. Sideris DI, et al. Among authors: knowles tpj, vendruscolo m. Brain Commun. 2021 Jul 2;3(3):fcab147. doi: 10.1093/braincomms/fcab147. eCollection 2021. Brain Commun. 2021. PMID: 34396107 Free PMC article.
Feedback control of protein aggregation.
Dear AJ, Michaels TCT, Knowles TPJ, Mahadevan L. Dear AJ, et al. Among authors: knowles tpj. J Chem Phys. 2021 Aug 14;155(6):064102. doi: 10.1063/5.0055925. J Chem Phys. 2021. PMID: 34391352
Quantitative Measurement of the Affinity of Toxic and Nontoxic Misfolded Protein Oligomers for Lipid Bilayers and of its Modulation by Lipid Composition and Trodusquemine.
Errico S, Ramshini H, Capitini C, Canale C, Spaziano M, Barbut D, Calamai M, Zasloff M, Oropesa-Nuñez R, Vendruscolo M, Chiti F. Errico S, et al. Among authors: vendruscolo m. ACS Chem Neurosci. 2021 Sep 1;12(17):3189-3202. doi: 10.1021/acschemneuro.1c00327. Epub 2021 Aug 12. ACS Chem Neurosci. 2021. PMID: 34382791 Free PMC article.
LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies.
Emmenegger M, De Cecco E, Hruska-Plochan M, Eninger T, Schneider MM, Barth M, Tantardini E, de Rossi P, Bacioglu M, Langston RG, Kaganovich A, Bengoa-Vergniory N, Gonzalez-Guerra A, Avar M, Heinzer D, Reimann R, Häsler LM, Herling TW, Matharu NS, Landeck N, Luk K, Melki R, Kahle PJ, Hornemann S, Knowles TPJ, Cookson MR, Polymenidou M, Jucker M, Aguzzi A. Emmenegger M, et al. Among authors: knowles tpj. EMBO Mol Med. 2021 Sep 7;13(9):e14745. doi: 10.15252/emmm.202114745. Epub 2021 Jul 26. EMBO Mol Med. 2021. PMID: 34309222 Free PMC article.
Calmodulin complexes with brain and muscle creatine kinase peptides.
Sprenger J, Trifan A, Patel N, Vanderbeck A, Bredfelt J, Tajkhorshid E, Rowlett R, Lo Leggio L, Åkerfeldt KS, Linse S. Sprenger J, et al. Among authors: linse s. Curr Res Struct Biol. 2021 May 19;3:121-132. doi: 10.1016/j.crstbi.2021.05.001. eCollection 2021. Curr Res Struct Biol. 2021. PMID: 34235492 Free PMC article.
The unhappy chaperone.
Linse S, Thalberg K, Knowles TPJ. Linse S, et al. Among authors: knowles tpj. QRB Discov. 2021 Jul 8;2:e7. doi: 10.1017/qrd.2021.5. eCollection 2021. QRB Discov. 2021. PMID: 37529680 Free PMC article.
Biomembranes in bioelectronic sensing.
Jayaram AK, Pappa AM, Ghosh S, Manzer ZA, Traberg WC, Knowles TPJ, Daniel S, Owens RM. Jayaram AK, et al. Among authors: knowles tpj. Trends Biotechnol. 2022 Jan;40(1):107-123. doi: 10.1016/j.tibtech.2021.06.001. Epub 2021 Jul 3. Trends Biotechnol. 2022. PMID: 34229865 Review.
Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers.
Limbocker R, Staats R, Chia S, Ruggeri FS, Mannini B, Xu CK, Perni M, Cascella R, Bigi A, Sasser LR, Block NR, Wright AK, Kreiser RP, Custy ET, Meisl G, Errico S, Habchi J, Flagmeier P, Kartanas T, Hollows JE, Nguyen LT, LeForte K, Barbut D, Kumita JR, Cecchi C, Zasloff M, Knowles TPJ, Dobson CM, Chiti F, Vendruscolo M. Limbocker R, et al. Among authors: knowles tpj, dobson cm, vendruscolo m. Front Neurosci. 2021 Jun 18;15:680026. doi: 10.3389/fnins.2021.680026. eCollection 2021. Front Neurosci. 2021. PMID: 34220435 Free PMC article.
Templating S100A9 amyloids on Aβ fibrillar surfaces revealed by charge detection mass spectrometry, microscopy, kinetic and microfluidic analyses.
Pansieri J, Iashchishyn IA, Fakhouri H, Ostojić L, Malisauskas M, Musteikyte G, Smirnovas V, Schneider MM, Scheidt T, Xu CK, Meisl G, Knowles TPJ, Gazit E, Antoine R, Morozova-Roche LA. Pansieri J, et al. Among authors: knowles tpj. Chem Sci. 2020 Jun 17;11(27):7031-7039. doi: 10.1039/c9sc05905a. Chem Sci. 2020. PMID: 34122996 Free PMC article.
Machine learning-aided protein identification from multidimensional signatures.
Zhang Y, Wright MA, Saar KL, Challa P, Morgunov AS, Peter QAE, Devenish S, Dobson CM, Knowles TPJ. Zhang Y, et al. Among authors: knowles tpj, dobson cm. Lab Chip. 2021 Aug 7;21(15):2922-2931. doi: 10.1039/d0lc01148g. Epub 2021 Jun 10. Lab Chip. 2021. PMID: 34109955 Free PMC article.
Generic nature of the condensed states of proteins.
Fuxreiter M, Vendruscolo M. Fuxreiter M, et al. Among authors: vendruscolo m. Nat Cell Biol. 2021 Jun;23(6):587-594. doi: 10.1038/s41556-021-00697-8. Epub 2021 Jun 9. Nat Cell Biol. 2021. PMID: 34108660 Review.
Cooperativity of α-Synuclein Binding to Lipid Membranes.
Makasewicz K, Wennmalm S, Stenqvist B, Fornasier M, Andersson A, Jönsson P, Linse S, Sparr E. Makasewicz K, et al. Among authors: linse s. ACS Chem Neurosci. 2021 Jun 16;12(12):2099-2109. doi: 10.1021/acschemneuro.1c00006. Epub 2021 Jun 2. ACS Chem Neurosci. 2021. PMID: 34076426 Free PMC article.
Charge Regulation during Amyloid Formation of α-Synuclein.
Pálmadóttir T, Malmendal A, Leiding T, Lund M, Linse S. Pálmadóttir T, et al. Among authors: linse s. J Am Chem Soc. 2021 May 26;143(20):7777-7791. doi: 10.1021/jacs.1c01925. Epub 2021 May 17. J Am Chem Soc. 2021. PMID: 33998793 Free PMC article.
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