Research paperReversion of multidrug resistance using nanoparticles in vitro: Influence of the nature of the polymer
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2017, Ultrasonics SonochemistryCitation Excerpt :Recent decades have witnessed several attempts to explore positive-charged nanoparticles (NPs) based strategies to overcome MDR [3]. For example, positive-charged Pluronic nanoparticles can participate in the enhancement of drug cytotoxicity [4,5]; the addition of resistance modulators or surfactants to PACA nanocarrier with positive charge increases intracellular drug concentration thereby reversing MDR [6]. Since cell surface is negative, positive charged NPs easily enter into cells resulting in efficient cellular uptake.
Overcoming cellular multidrug resistance using classical nanomedicine formulations
2012, European Journal of Pharmaceutical SciencesCitation Excerpt :Nanomedicines do not cross the cellular membrane in ‘free’ form, but are incorporated into endocytotic vesicles, thereby preventing them from being recognized by efflux pumps. Upon this shuttling across the cellular membrane, nanomedicines and/or the drug molecules released from them during endo-lysosomal trafficking, are delivered deeply into (cancer) cells, and thereby are able, at least to some extent, to bypass Pgp- and MRP-mediated efflux mechanisms (Thierry et al., 1992; Cuvier et al., 1992; Nemati et al., 1996; de Verdiare et al., 1997; Minko et al., 1998, 1999; Goren et al., 2000; Mayer and Shabbits, 2001; Mamot et al., 2003; Duncan, 2006; Sahay et al., 2010). Many studies that aimed to assess the ability of nanomedicines to overcome multidrug resistance, however, are based on the use of semi-artificial in vitro models, i.e. on cells transfected with plasmid DNA encoding for Pgp and/or MRP.