Preparation techniques and mechanisms of formation of biodegradable nanoparticles from preformed polymers

Drug Dev Ind Pharm. 1998 Dec;24(12):1113-28. doi: 10.3109/03639049809108571.

Abstract

The techniques available to prepare biodegradable nanoparticles (nanospheres and nanocapsules) from preformed polymers are reviewed. Although there is abundant literature on this topic, only a few focus on the thorough analysis of preparative procedures. In particular, four techniques are discussed in terms of their technological advantages and drawbacks: emulsification evaporation, solvent displacement, salting-out, and emulsification diffusion. The proposed mechanism of nanoparticle formation for each technique is described from a physicochemical perspective. The effects of preparative variables on nanoparticle size and drug-entrapment efficiency are also discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biodegradation, Environmental
  • Diffusion
  • Drug Delivery Systems
  • Emulsions
  • Microspheres
  • Polymers*

Substances

  • Emulsions
  • Polymers