Interstitial macrophages are a focus of viral takeover and inflammation in COVID-19 initiation in human lung.
Wu TT, Travaglini KJ, Rustagi A, Xu D, Zhang Y, Andronov L, Jang S, Gillich A, Dehghannasiri R, Martínez-Colón GJ, Beck A, Liu DD, Wilk AJ, Morri M, Trope WL, Bierman R, Weissman IL, Shrager JB, Quake SR, Kuo CS, Salzman J, Moerner WE, Kim PS, Blish CA, Krasnow MA.
Wu TT, et al.
J Exp Med. 2024 Jun 3;221(6):e20232192. doi: 10.1084/jem.20232192. Epub 2024 Apr 10.
J Exp Med. 2024.
PMID: 38597954
Free PMC article.
Early stages of deadly respiratory diseases including COVID-19 are challenging to elucidate in humans. Here, we define cellular tropism and transcriptomic effects of SARS-CoV-2 virus by productively infecting healthy human lung tissue and using scRNA-seq to reconstr …
Early stages of deadly respiratory diseases including COVID-19 are challenging to elucidate in humans. Here, we define cellula …