Lipomatous variant of angiomyofibroblastoma: a case report and review of the literature

J Cutan Pathol. 2015 Mar;42(3):222-226. doi: 10.1111/cup.12450. Epub 2015 Jan 9.

Abstract

Angiomyofibroblastoma represents a rare, benign mesenchymal tumor with a predilection for the vulvovaginal region. Lipomatous change may occur but rarely comprises a substantial component of the lesion. There are only eight reports in the English language literature describing the lipomatous variant of this tumor. We describe a further lipomatous angiomyofibroblastoma that occurred on the labium majus of a 49-year-old woman. The histopathologic and immunohistochemical features are described, and the collective experience in the literature is reviewed.

Keywords: FISH; histopathology; immunohistochemistry; soft tissue tumors.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Angiofibroma / diagnosis
  • Angiofibroma / pathology*
  • Angiofibroma / surgery
  • Angiomyoma / diagnosis
  • Angiomyoma / pathology*
  • Angiomyoma / surgery
  • Bartholin's Glands / pathology
  • Diagnosis, Differential
  • Female
  • Humans
  • Mesoderm / pathology
  • Mesoderm / surgery
  • Middle Aged
  • Soft Tissue Neoplasms / diagnosis
  • Soft Tissue Neoplasms / pathology*
  • Soft Tissue Neoplasms / surgery
  • Vulvar Neoplasms / diagnosis
  • Vulvar Neoplasms / pathology
  • Vulvar Neoplasms / surgery
  • Vulvar Neoplasms / ultrastructure