Definition of virological breakthrough
VBT is defined as any increase in serum HBV DNA by an amount >1 log10 from nadir or redetection of serum HBV DNA at levels 10-fold over the lower limit of detection of the viral load after HBV DNA becomes undetectable.
Aug 30, 2019
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Jun 30, 2014 · Virologic breakthrough in a patient with chronic hepatitis B by combination treatment with tenofovir disoproxil fumarate and entecavir.
We aimed to determine the rate of HBV recurrence after orthotopic liver transplantation (OLT) in relation to virologic breakthrough pre-OLT and HBIG regimens ...
Virologic breakthrough (VBT) may occur in chronic hepatitis B (CHB) patients after switching from nucleos(t)ide analogues (NAs) to pegylated interferon ...
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virologic breakthrough with continued treatment. ... HBV, Hepatitis B virus. Table 3 Relation between pre ... HBV genotypes among Egyptian hepatitis patients.
Fortunately, virologic failure, which may include an on-treatment virologic breakthrough/nonresponse or a post-treatment virologic relapse, is infrequent with ...
Virologic response was defined as achieving undetectable serum HBV DNA level (<20 IU/mL) during the treatment period. Virologic breakthrough was defined as an ...
Jul 23, 2010 · We aimed to determine the rate of HBV recurrence after orthotopic liver transplantation (OLT) in relation to virologic breakthrough pre-OLT and ...
†Virologic breakthrough was defined as an increase in HBV DNA of 1 log in copies/mL from the on-treatment nadir, as determined by at least two sequential.
We investigated the course of virologic breakthrough (VB) after emergence of YMDD mutants in CHB patients receiving lamivudine. Methods: Ninety-three ...
Nov 14, 2023 · 2 consecutive visits; viral blip: met 1 virologic breakthrough criterion at only 1 visit; viremia: persistent HBV DNA ≥69 IU/mL over ...
In addition, genotyping was performed on isolates from patients experiencing virologic breakthrough (>or = 1 log(10) rise in HBV DNA). In vitro phenotypic ETV ...
Aug 8, 2011 · In our study, the rate of virologic breakthrough in the ETV group was higher than that in the LAM plus ADV group and Lee et al. [26] found that ...
Apr 6, 2024 · Here, we report for the first time a patient with chronic hepatitis B and cirrhosis who emerged with virologic breakthrough during combination ...
... Hepatology. Hepatology. 3. All ... As for the patients experiencing a virologic breakthrough ... Entecavir is a potent inhibitor of hepatitis B virus (HBV) ...
Results: The median duration of therapy was 25 (9-57) mo. Virologic breakthrough was defined as a > 1 log HBV DNA increase following initial suppression. When ...
Keywords Chronic HBV, lamivudine, HBeAg, virologic response, virologic breakthrough. Ann Gastroenterol 2014; 27 (4): 380-386. Introduction. Approximately one ...
... hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. ... hepatitis B virus (HBV) and hepatitis C virus (HCV). ... virologic breakthrough occurs, defined ...
Oct 17, 2023 · The virologic response was defined as serum HBV DNA below the detection limit (100 IU/mL). The virologic breakthrough was defined as increased ...
precore mutant hepatitis B virus (HBV) chronic liver disease under long-term lamivudine ... more after virologic breakthrough (HBV DNA, 116,440 copies/mL only on ...
[14] describe five patients with a virologic breakthrough during adefovir dipivoxil. (ADV) treatment in the absence of known ADV-resis- tant mutations, and ...
Virologic breakthrough (VBT) was defined as HBV DNA elevation more than 1 log10 from nadir. Genotypic mutation to ADV was detected using mass spectrometry-based ...
Jan 16, 2014 · Virologic breakthrough during the treatment period was defined as a confirmed increase from the nadir in the HCV RNA level of at least 1 log10 ...
Jul 27, 2021 · Clinically, antiviral resistance manifests as virologic breakthrough, defined as a ≥1 log10 IU/mL increase in serum HBV DNA levels from ...
Jan 28, 2016 · ... (HIV), hepatitis C virus, or hepatitis D virus. ... virologic breakthrough (defined as patients ... Lamivudine for patients with chronic hepatitis B ...
Dec 19, 2023 · Cases of hepatitis B virus (HBV) ... virologic breakthrough (Lawitz, 2014a); (Schneider, 2014). ... liver disease or alcoholic liver disease. Among ...
Partial virologic response is defined as a reduction of greater than 1 log10 IU/ml but detectable HBV DNA by RT PCR assay. Virologic breakthrough or secondary ...
... HBV DNA at year 3. The cumulative rate of entecavir-resistant mutations was 1.2% at year 3. Three patients experienced virologic breakthrough, one with ...
Virologic breakthrough in a patient with chronic hepatitis B by combination treatment with tenofovir disoproxil fumarate and entecavir · Dove Medical Press ...
Sep 26, 2017 · After virologic breakthrough (detected at 48 weeks), HBV-DNA levels ... Challenges face clinicians treating HbeAg negative chronic hepatitis B in ...
Jul 1, 2016 · ... hepatitis B envelop antibody (anti-HBe). No hepatitis B surface antigen (HBsAg) loss and virologic breakthrough were detected in NA-naïve ...
Dec 15, 2019 · Predictably, virologic breakthrough was soon demonstrated in a number of lamivudine-treated patients. European, American and most of the ...
The first manifestation of antiviral resistance is virologic breakthrough which is defined as a >1log10 increase in serum HBV DNA from nadir during treatment in ...
In a compliant patient, it is important to distinguish between primary nonresponse, partial virologic response, and virologic breakthrough (viral rebound) owing ...
Virologic breakthrough during antiviral therapy was defined as ≥1 log in- crease in serum HBV DNA from nadir or redetection of HBV DNA in serum after its ...
term monitoring of HBV DNA. The development of resistance can result in virologic breakthrough and liver complications. Entecavir and tenofovir represent ...
tectable HBV DNA on entecavir, 5 (7%) developed entecavir resistance.58 All patients with entecavir virologic breakthrough at year 5 had HBV virus with.
Apr 8, 2019 · Virologic breakthrough (VBT) was defined as an increase in serum HBV ... Lamivudine for patients with chronic hepatitis B and advanced liver ...
Dec 16, 2018 · Consequently, multidrug-resistant (MDR) hepatitis B virus (HBV) has emerged [4, 5]. ... Minor virologic breakthrough was defined as any ...
New Virologic Tools for Management of Chronic Hepatitis B and C
www.gastrojournal.org › article › pdf
(HBV) and hepatitis C virus (HCV). ... hepatitis B surface antigen; HBV, hepatitis B virus; HCV, hepatitis C ... and detect virologic breakthrough and relapse.
Mar 9, 2017 · Virologic breakthrough (VBT) was defined as an increase over 1 log10 IU/mL of serum HBV DNA levels from the nadir during the therapy or ...
Overview of Hepatitis B and C Management - U.S. Pharmacist
www.uspharmacist.com › article › overvi...
Dec 17, 2009 · Unfortunately, LAM has been associated with a high rate of resistance (up to 70% after 5 years) and virologic breakthrough, thus limiting its ...
High HBV-DNA load before treatment was shown to be an important factor causing virologic breakthrough. Early suppression of viral replication plays a key role ...
Nov 16, 2015 · All adverse events were graded according to a standardized scale. Virologic breakthrough was defined as detectable HCV RNA during treatment in a ...
Tenofovir Monotherapy versus Tenofovir plus Lamivudine or ...
journals.asm.org › ... › Vol. 59, No. 2
Jan 27, 2015 · Hepatitis B e antigen (HBeAg) loss, biochemical response, and virologic breakthrough did not differ between treatment groups. The probabilities ...
Jan 18, 2023 · The only confirmed virologic failure was virologic breakthrough at week 8 in a participant with genotype 3 and cirrhosis. Both regimens were ...
The visit window was ±2 weeks. Genotypic analysis was performed at baseline and in cases of virologic breakthrough (increase of HBV DNA levels >1 log IU/mL from ...
B virus (HBV), Hepatitis C virus (HCV) or Hepatitis ... HCV RNA; Quantitative HBV DNA; Quantitative HCV RNA; Viral hepatitis ... Virologic breakthrough: 1 log ...
May 5, 2015 · ... HCV-RNA of 1000 IU/mL or greater from patients with virologic failure, defined as virologic breakthrough, detectable HCV-RNA at end of ...
Virologic breakthrough was defined as a confirmed rise in HBV DNA levels, and confirmed HBV DNA rises were those in which the next treatment visit also had ...
Abbreviations: HBV, hepatitis ... virologic breakthrough than group 2 (HR, 2.870 ... a Abbreviations: HBV, hepatitis B virus; LC, liver cirrhosis; HBeAg, hepatitis ...
The biochemical and serologic responses, virologic breakthrough, and antiviral resistance rates were also evaluated. ... HBV, hepatitis B virus; HCC, ...
... virologic breakthrough characterized by a return to baseline replication levels. Pre-emptive or prophylactic administration of lamivudine was shown to ...
Add-on adefovir dipivoxil would be prescribed in case of virologic breakthrough, defined as an increase of serum HBV DNA level for at least 1 log from the nadir ...
Long-term viral suppression with VEMLIDY through 5 years · Virologic breakthrough (2 consecutive visits with HBV DNA ≥69 IU/mL [400 copies/mL] after having been ...
virologic breakthrough was not different in the three subgroups of patients. † LAM was stopped in 80 patients (13.5%); in 43 patients the drug was stopped ...
Oct 13, 2016 · Chronic hepatitis B virus (HBV) infection causes necroinflammatory liver disease, cirrhosis, and ... virologic breakthrough with HBV DNA 3.58 ...
Jan 16, 2018 · ... disease or other chronic liver disease ... virologic breakthrough and genotypic mutation. ... HBV = hepatitis B virus, ETV = entecavir, LAM = ...
Mar 15, 2023 · In 11 cases, a virologic breakthrough (>1 log-increase in HDV RNA after virologic response) was observed. After 24 weeks of treatment, 19/33 ...
ulin; HBsAg, hepatitis B surface antigen; HBV, hepatitis B virus; HCC, ... HBV infection based upon HBV and liver disease ... manifests as virologic breakthrough, ...
treatment, a virologic breakthrough indicated by return to positive HCV-RNA at any time during treatment, and relapse indicated by a positive HCV-RNA ...
virologic breakthrough. Moreover, 2% of these ... (PCR) assay (COBAS AmpliPrep Hepatitis B Virus (HBV) Test: HBV ... chronic hepatitis B and advanced liver disease.
Dive into the research topics of 'Clinical course of virologic breakthrough after emergence of YMDD mutations in HBeAg-positive chronic hepatitis B'. Together ...
Virologic breakthrough was defined as an increase in the serum HBV DNA level of more than 1 log10 IU/mL from the nadir during continued treatment. In those ...
Virologic breakthrough patients with HBV DNA greater than 159 IU/mL underwent deep sequencing. In virologic breakthrough patients who were adherent to the study ...
The virologic response was maintained in 67 percent, while HBsAg clearance was observed in 12 percent. Virologic breakthrough occurred in one-third of patients ...
Hepatitis C virus (HCV) infection causes acute and chronic hepatitis ... disease, or alcoholic liver disease. ... virologic breakthrough (VBT), reappearance of HCV ...
Jan 20, 2011 · STEP 7: Manage treatment failure or virologic breakthrough. Page 9. Federal Bureau of Prisons. Detecting, Evaluating, and Treating Chronic HBV ...
... virologic breakthrough (>1 log10 copies/mL increase in HBV DNA level above nadir on two consecutive occasions) were retrospectively analyzed. Results: The ...
Pretreatment and on-treatment indicators of virologic breakthrough of lamivudine therapy in chronic hepatitis B patients: an Egyptian study. Montasser MF ...
May 28, 2014 · In the Yuen study, three patients out of 222 experienced virologic breakthrough, one with resistance development, one with subsequent HBe Ag ...
May 7, 2018 · ... (virologic breakthrough) and then by an ... The rtA194T HBV polymerase mutation that was recently identified in HIV/HBV ... Lamivudine for patients ...
Preventing emergence of resistance and virologic breakthrough may best be achieved by using an agent or combination of agents with a high genetic barrier to ...
Virologic breakthrough is defined as an increase in serum HBV DNA >1 log IU/ml from the nadir of the initial response during therapy, as confirmed 1 month later ...
... HCV RNA at the end of therapy; (4) virologic breakthrough: HCV RNA reappearance in serum while still on treatment;(5)sustained virologic response (SVR): PCR ...
Jun 30, 2012 · Virologic breakthrough is defined as an increase in serum HBV DNA of more than 1 log10 (IU/mL) compared to lowest value. Partial virologic ...
Oct 16, 2014 · A virologic breakthrough was defined as an increase in the serum HBV ... Hepatitis B virus replication and liver disease progression: the impact ...
Lamivudine Chronic hepatitis B Virologic breakthrough. Clinical breakthrough. Abstract. Objective: High rate of resistance to lamivudine is a major problem in ...
Apr 23, 2013 · ... HBV DNA from baseline but still detectable after 6 months (in compliant patients). iv. Virologic breakthrough: increase in HBV DNA >1 log10 ...
Hepatitis B treatment: Current best practices, avoiding resistance
www.ccjm.org › content › 5_suppl_3
May 1, 2009 · The development of resistance to therapy can result in virologic breakthrough and serious clinical consequences. Use of the most potent ...
... virologic breakthrough and resistance selection and numerically lower SVR rates for subjects with genotype 1a HCV infection, because of selection of R155K ...
Aug 30, 2008 · Patients who experienced a virologic breakthrough, defined as two consecutive HBV DNA measurements ≥1 log10 above nadir during weeks 52–96 ...
May 29, 2014 · Virologic breakthrough was defined by either an increase of serum HBV-DNA by at least 1 log copy/mL. Statistical analysis. Results are ...
... virologic breakthrough, or relapse. As part of the PROVIDE study, patients received 4 weeks of lead-in therapy with peginterferon and ribavirin if it had ...
... HCV-1 infected patients. Several patients in the group receiving the induction therapy showed a virologic breakthrough when the interval of interferon-α ...
Aug 14, 2007 · ... HBV DNA level is the most important factor associated with virologic breakthrough in chronic hepatitis B treated with lamivudine." (2007) ...
Apr 8, 2019 · Virologic breakthrough (VBT) was defined as an increase in serum HBV ... Lamivudine for patients with chronic hepatitis B and advanced liver ...
May 22, 2012 · variants should be suspected if virologic breakthrough occurs, defined as a re-increase in the HBV DNA level by 1 Log10 or more above the ...
Feb 23, 2023 · "Impact of virologic breakthrough and HBIG regimen on hepatitis B recurrence after liver transplantation." American Journal of ...
Feb 28, 2018 · "Impact of virologic breakthrough and HBIG regimen on hepatitis B recurrence after liver transplantation. ... liver? Hepatitis and liver disease.
Nov 30, 2008 · ... Hepatitis B vaccine). © 2024 HealthCentral ... HIV disease. ... Late virologic breakthrough in treatment-naive patients on a regimen of Combivir + ...
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