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catRAPID omics v2.0

Your submission results


Information about the JOB:

ID: 395496
User label: Apt-1_TDP-43_Protein_fitness_referee
Valid submitted sequences: Protein
Valid submitted sequences: RNA
Non-valid submitted sequences: RNA
Non-valid submitted sequences: Protein
Generated: 2021-09-29 11:01:05.370852
Organism: notknown
RNA type: not specified



Download .pdf


Top results:


Protein ID

RNA ID

Interaction Propensity

A measure of the interaction probability between one protein (or region) and one RNA (or region). This measure is based on the observed tendency of the components of ribonucleoprotein complexes to exhibit specific properties of their physico-chemical profiles that can be used to make a prediction (Bellucci et al. [Nat Methods. 2011]). The reported value is that of the Top RNA fragment (see Performances).

Z-score

The Interaction Propensity normalised with mean and standard deviation of all fragments. In the catRAPID omics module, the Z-score is normalized using mean = 23.25 and standard deviation = 37.90 that were calculated on two reference sets. The highest value among all fragments is reported.

Interaction Matrix

The second plot is the interaction matrix that shows, as a heat-map, the protein (y-axis) and RNA (x-axis) regions predicted to interact. The shades of red of the heat-map indicate the interaction score of the individual amino acid and nucleotide pairs.

RBP propensity

A measure of the propensity of the protein to bind RNA. It equals 1 if the protein is in the RBP precompiled library or it is similar to one of such RBPs. Otherwise, it is set to catRAPID signature overall score.

RNA-Binding Domains

Number of RNA-binding domain occurrences found in the protein sequence.

RNA-Binding Motifs

Number of RNA-binding motifs instances found on the RNA sequence.

Conserved Interactions

RBP-RNA pairs orthologous to the top 500 pairs (based on Interaction Propensity, giving higher priority to proteins with higher RBP propensity) undergo a parallel catRAPID analysis. If z-score is is higher than the value in z-score column minus 0.5, the interaction is classified as conserved. The column reports the number of organisms in which the interaction is conserved out of those in which an orthologous pair is found.

Ranking

The score is the sum of three individual values: 1) catRAPID normalized propensity, 2) RBP propensity and 3) presence of known RNA-binding motif.
p.1 Apt.1 1.96 -0.56 table|plot 1 3 0 0/0
0.476594
p.100 Apt.1 1.97 -0.56 table|plot 0.71 0 0 0/0
0.379938
p.11 Apt.1 1.17 -0.58 table|plot 0.69 0 0 0/0
0.372392
p.12 Apt.1 1.17 -0.58 table|plot 0.57 0 0 0/0
0.332392
p.13 Apt.1 1.18 -0.58 table|plot 0.61 0 0 0/0
0.345737
p.14 Apt.1 1.18 -0.58 table|plot 0.7 0 0 0/0
0.375737
p.17 Apt.1 1.19 -0.58 table|plot 0.68 0 0 0/0
0.369081
p.19 Apt.1 1.2 -0.58 table|plot 0.56 0 0 0/0
0.329092
p.20 Apt.1 1.21 -0.58 table|plot 0.63 0 0 0/0
0.352436
p.21 Apt.1 1.22 -0.58 table|plot 0.53 0 0 0/0
0.319114
p.25 Apt.1 1.25 -0.58 table|plot 0.58 0 0 0/0
0.335814
p.26 Apt.1 1.26 -0.58 table|plot 0.51 0 0 0/0
0.312491
p.27 Apt.1 1.26 -0.58 table|plot 0.55 0 0 0/0
0.325825
p.28 Apt.1 1.27 -0.58 table|plot 0.69 0 0 0/0
0.372502
p.3 Apt.1 1.12 -0.58 table|plot 0.6 0 0 0/0
0.342337
p.32 Apt.1 1.29 -0.58 table|plot 0.53 0 0 0/0
0.319191
p.33 Apt.1 1.29 -0.58 table|plot 0.61 0 0 0/0
0.345858
p.34 Apt.1 1.3 -0.58 table|plot 0.57 0 0 0/0
0.332535
p.36 Apt.1 1.31 -0.58 table|plot 0.61 0 0 0/0
0.34588
p.37 Apt.1 1.32 -0.58 table|plot 0.84 0 0 0/0
0.422557
p.39 Apt.1 1.33 -0.58 table|plot 0.59 0 0 0/0
0.339235
p.4 Apt.1 1.13 -0.58 table|plot 0.55 0 0 0/0
0.325682
p.40 Apt.1 1.33 -0.58 table|plot 0.57 0 0 0/0
0.332568
p.44 Apt.1 1.38 -0.58 table|plot 0.74 0 0 0/0
0.38929
p.46 Apt.1 1.39 -0.58 table|plot 0.91 0 0 0/0
0.445967
p.47 Apt.1 1.4 -0.58 table|plot 0.56 0 0 0/0
0.329312
p.48 Apt.1 1.41 -0.58 table|plot 0.63 0 0 0/0
0.352656
p.49 Apt.1 1.42 -0.58 table|plot 0.76 0 0 0/0
0.396
p.5 Apt.1 1.13 -0.58 table|plot 0.53 0 0 0/0
0.319015
p.50 Apt.1 1.43 -0.58 table|plot 0.54 0 0 0/0
0.322678
p.52 Apt.1 1.44 -0.58 table|plot 0.65 0 0 0/0
0.359356
p.53 Apt.1 1.44 -0.58 table|plot 0.63 0 0 0/0
0.352689
p.58 Apt.1 1.45 -0.58 table|plot 0.56 0 0 0/0
0.329367
p.59 Apt.1 1.45 -0.58 table|plot 0.64 0 0 0/0
0.356033
p.60 Apt.1 1.48 -0.57 table|plot 0.64 0 0 0/0
0.356066
p.61 Apt.1 1.5 -0.57 table|plot 0.62 0 0 0/0
0.349422
p.62 Apt.1 1.5 -0.57 table|plot 0.67 0 0 0/0
0.366088
p.64 Apt.1 1.51 -0.57 table|plot 0.65 0 0 0/0
0.359433
p.65 Apt.1 1.51 -0.57 table|plot 0.78 0 0 0/0
0.402766
p.66 Apt.1 1.52 -0.57 table|plot 0.65 0 0 0/0
0.359444
p.67 Apt.1 1.52 -0.57 table|plot 0.66 0 0 0/0
0.362777
p.69 Apt.1 1.54 -0.57 table|plot 0.69 0 0 0/0
0.372799
p.70 Apt.1 1.55 -0.57 table|plot 0.78 0 0 0/0
0.40281
p.71 Apt.1 1.55 -0.57 table|plot 0.59 0 0 0/0
0.339477
p.74 Apt.1 1.57 -0.57 table|plot 0.72 0 0 0/0
0.382832
p.75 Apt.1 1.57 -0.57 table|plot 0.72 0 0 0/0
0.382832
p.77 Apt.1 1.6 -0.57 table|plot 0.53 0 0 0/0
0.319532
p.78 Apt.1 1.61 -0.57 table|plot 0.63 0 0 0/0
0.352876
p.8 Apt.1 1.15 -0.58 table|plot 0.66 0 0 0/0
0.36237
p.81 Apt.1 1.64 -0.57 table|plot 0.58 0 0 0/0
0.336242
p.84 Apt.1 1.68 -0.57 table|plot 0.52 0 0 0/0
0.316286
p.85 Apt.1 1.69 -0.57 table|plot 0.55 0 0 0/0
0.326297
p.86 Apt.1 1.7 -0.57 table|plot 0.56 0 0 0/0
0.329642
p.87 Apt.1 1.71 -0.57 table|plot 0.52 0 0 0/0
0.316319
p.88 Apt.1 1.72 -0.57 table|plot 0.57 0 0 0/0
0.332997
p.89 Apt.1 1.75 -0.57 table|plot 0.54 0 0 0/0
0.32303
p.91 Apt.1 1.8 -0.57 table|plot 0.53 0 0 0/0
0.319752
p.92 Apt.1 1.8 -0.57 table|plot 0.59 0 0 0/0
0.339752
p.93 Apt.1 1.81 -0.57 table|plot 0.76 0 0 0/0
0.396429



Download the table with all computed interactions pairs in reduced form (only the top-scoring RNA fragment for each protein-RNA pair) and full form (all the RNA fragments) as .zip files.