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Year Number of Results
1980 1
1986 1
1987 1
1988 2
1989 1
1991 1
1992 1
1994 1
1995 2
1996 2
1997 2
1998 5
1999 6
2000 5
2001 2
2002 6
2003 9
2004 4
2005 8
2006 10
2007 9
2008 9
2009 5
2010 6
2011 4
2012 9
2013 9
2014 5
2015 5
2016 8
2017 6
2018 3
2019 13
2020 10
2021 9
2022 8
2023 11
2024 2

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190 results

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Page 1
Protection against cancer by dietary IP6 and inositol.
Vucenik I, Shamsuddin AM. Vucenik I, et al. Nutr Cancer. 2006;55(2):109-25. doi: 10.1207/s15327914nc5502_1. Nutr Cancer. 2006. PMID: 17044765 Review.
For a long time IP(6) has been recognized as a natural antioxidant. Recently IP(6) has received much attention for its role in cancer prevention and control of experimental tumor growth, progression, and metastasis. ...Preliminary studies in humans show that IP(6) and inos …
For a long time IP(6) has been recognized as a natural antioxidant. Recently IP(6) has received much attention for its role in cancer …
Role of Inositols and Inositol Phosphates in Energy Metabolism.
Chatree S, Thongmaen N, Tantivejkul K, Sitticharoon C, Vucenik I. Chatree S, et al. Molecules. 2020 Nov 1;25(21):5079. doi: 10.3390/molecules25215079. Molecules. 2020. PMID: 33139672 Free PMC article. Review.
Recently, inositols, especially myo-inositol and inositol hexakisphosphate, also known as phytic acid or IP6, with their biological activities received much attention for their role in multiple health beneficial effects. Although their roles in cancer treatment and …
Recently, inositols, especially myo-inositol and inositol hexakisphosphate, also known as phytic acid or IP6, with their biological a …
Cellular and Molecular Activities of IP6 in Disease Prevention and Therapy.
Dilworth L, Stennett D, Omoruyi F. Dilworth L, et al. Biomolecules. 2023 Jun 10;13(6):972. doi: 10.3390/biom13060972. Biomolecules. 2023. PMID: 37371552 Free PMC article. Review.
IP6 (phytic acid) is a naturally occurring compound in plant seeds and grains. ...It has also been shown to possess anti-inflammatory properties that may modulate immune responses geared towards the prevention of inflammatory conditions. Moreover, IP6 exhibits anti- …
IP6 (phytic acid) is a naturally occurring compound in plant seeds and grains. ...It has also been shown to possess anti-inflammatory …
Inositol Hexaphosphate (IP6) and Colon Cancer: From Concepts and First Experiments to Clinical Application.
Vucenik I, Druzijanic A, Druzijanic N. Vucenik I, et al. Molecules. 2020 Dec 15;25(24):5931. doi: 10.3390/molecules25245931. Molecules. 2020. PMID: 33333775 Free PMC article. Review.
Although Ins possesses a modest anticancer potential, the best anticancer results were obtained from the combination of IP6 + Ins. Here we review the first experimental steps in colon cancer, when concepts and hypotheses were put together almost without real knowled …
Although Ins possesses a modest anticancer potential, the best anticancer results were obtained from the combination of IP6 + Ins. He …
Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic.
Vucenik I, Shamsuddin AM. Vucenik I, et al. J Nutr. 2003 Nov;133(11 Suppl 1):3778S-3784S. doi: 10.1093/jn/133.11.3778S. J Nutr. 2003. PMID: 14608114 Review.
IP6 plus inositol enhances the anticancer effect of conventional chemotherapy, controls cancer metastases, and improves the quality of life, as shown in a pilot clinical trial. The data strongly argue for the use of IP6 plus inositol in our strategies for …
IP6 plus inositol enhances the anticancer effect of conventional chemotherapy, controls cancer metastases, and improves the qu …
Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction.
Kefala Stavridi A, Gontier A, Morin V, Frit P, Ropars V, Barboule N, Racca C, Jonchhe S, Morten MJ, Andreani J, Rak A, Legrand P, Bourand-Plantefol A, Hardwick SW, Chirgadze DY, Davey P, De Oliveira TM, Rothenberg E, Britton S, Calsou P, Blundell TL, Varela PF, Chaplin AK, Charbonnier JB. Kefala Stavridi A, et al. Nucleic Acids Res. 2023 Nov 27;51(21):11732-11747. doi: 10.1093/nar/gkad863. Nucleic Acids Res. 2023. PMID: 37870477 Free PMC article.
We report cryo-EM structures of apo- and DNA-bound Ku in complex with IP6, at 3.5 A and 2.74 A resolutions respectively, and an X-ray crystallography structure of a Ku in complex with DNA and IP6 at 3.7 A. The Ku-IP6 interaction is mediated predominantly via …
We report cryo-EM structures of apo- and DNA-bound Ku in complex with IP6, at 3.5 A and 2.74 A resolutions respectively, and an X-ray …
IP6: a novel anti-cancer agent.
Shamsuddin AM, Vucenik I, Cole KE. Shamsuddin AM, et al. Life Sci. 1997;61(4):343-54. doi: 10.1016/s0024-3205(97)00092-1. Life Sci. 1997. PMID: 9244360 Review.
A striking anti-cancer action of IP6 has been demonstrated both in vivo and in vitro, which is based on the hypotheses that exogenously administered IP6 may be internalized, dephosphorylated to IP(1-5), and inhibit cell growth. There is additional evidence th …
A striking anti-cancer action of IP6 has been demonstrated both in vivo and in vitro, which is based on the hypotheses that ex …
Structural basis of HIV-1 maturation inhibitor binding and activity.
Sarkar S, Zadrozny KK, Zadorozhnyi R, Russell RW, Quinn CM, Kleinpeter A, Ablan S, Meshkin H, Perilla JR, Freed EO, Ganser-Pornillos BK, Pornillos O, Gronenborn AM, Polenova T. Sarkar S, et al. Nat Commun. 2023 Mar 4;14(1):1237. doi: 10.1038/s41467-023-36569-y. Nat Commun. 2023. PMID: 36871077 Free PMC article.
We report atomic-resolution magic-angle-spinning NMR structures of microcrystalline assemblies of CA(CTD)-SP1 complexed with BVM and/or the assembly cofactor inositol hexakisphosphate (IP6). Our results reveal a mechanism by which BVM disrupts maturation, tightening the 6- …
We report atomic-resolution magic-angle-spinning NMR structures of microcrystalline assemblies of CA(CTD)-SP1 complexed with BVM and/or the …
Metabolism and cellular functions of IP6: a review.
Shamsuddin AM. Shamsuddin AM. Anticancer Res. 1999 Sep-Oct;19(5A):3733-6. Anticancer Res. 1999. PMID: 10625949 Review.
Inositol hexaphosphate (IP6) has a demonstrably effective anti-cancer action against a variety of experimental tumors. ...The rate and pattern at which IP6 is metabolized by cancer cells varies depending on the cell type. ...
Inositol hexaphosphate (IP6) has a demonstrably effective anti-cancer action against a variety of experimental tumors. ...The …
190 results