GC–MS ANALYSIS OF BIOACTIVE COMPOUNDS PRESENT IN ETHANOLIC LEAF EXTRACT Acalypha indica
S. AZHAGU MADHAVAN
*
Department of Zoology and Biotechnology, A. Veeriya Vandayar Memorial Sri Pushpam College, (Autonomous) Poondi, Thanjavur – 613503, Tamil Nadu, India.
*Author to whom correspondence should be addressed.
Abstract
Plant extracts protect against toxic chemical-induced injury by increasing the body’s levels of antioxidant molecules, such as glutathione, and enhancing the activity of antioxidant enzymes. Acalypha indica distributed in the southern part of India particularly in Tamilnadu has potential medicinal properties and it is used as diuretic, anthelmintic and for respiratory problems such as bronchitis, asthma and pneumonia. Phytochemical secondary metabolites presences and absences in phytochemical screening by GC-MS revealed of 7 major bioactive compounds. Extracts of Acalypha indica may be useful in formulating and synthesizing new antibacterial drugs.
Keywords: Acalypha indica, GC-MS, phytochemicals, natural antibiotic properties.
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Meena MK, Singh N, Patni V. Determination of bioactive components of the leaves of Cocculus hirsutus (L.) diels using GC-MS analysis. Int. J. Pharm. Pharm. Sci. 2014;6:327-329.
Kawatu CB, Mongi J. Test on the effect of ethanol extract of anting-anting leaf (Acalypha indica L.) on Blood Sugar Levels of Male White Mouse Wistar (Rattus novergicus) (Uji Efek Ekstrak Etanol Daun Anting-Anting (Acalypha indica L.) Terhadap Kadar Gula Darah Tikus Putih Jantan Galur Wistar (Rattus novergicus). Pharmacon. 2013;81-85.
Zong A, Cao H, Wang F. Anticancer polysaccharides from natural resources: a review of recent research. Carbohydrate Polymers. 2012;90(4):1395–1410.
Hossain MA, Al-Toubi WA, Al-Sabahi JN, Weli AM, Al-Riyami QA. Identification and characterization of chemical compounds in different crude extracts from leaves of Omani neem. Journal of Taibah University for Science. 2013;7:181–188.
Francine U, Jeannette U, Pierre RJ. Assessment of antibacterial activity of Neem plant (Azadirachta indica) on Staphylococcus aureus and Escherichia. Journal of Medicinal Plants Studies. 2015;3(4):85-91.
Lee EJ, Oh H, Kang BG, Kang MK, Kim DY, Lee JY, et al. Lipid-lowering effects of medium-chain triglyceride-enriched coconut oil in combination with licorice extracts in experimental hyperlipidemic mice. J Agric Food Chem. 2018;66:10447-57.
Efferth T, Koch E. Complex interactions between Phytochemicals. The multi-target therapeutic concept of Phytotherapy. Current Drug Targets. 2012l12(1):122–132.
Chandra Mohan S, Dinakar S, Anand T, Elayaraja R, SathiyaPriya B. Phytochemical, GC-MS analysis and Antibacterial activity of a Medicinal Plant Acalypha indica Int. J. Pharm Tech Res. 2012;4(3).
Sushmitha HS, Balasubramanian Sathyamurthy. In silico drug designing studies on Dengue Virus NS2BNS3 Protease‖. Indo American Journal of Pharmaceutical Sciences. 2018;5(8):7784–7790.
Ranju G, Niranjan S, Kumar PS, Kumar PV, Kumar PS. In vitro Anthelmintic Activity of Acalypha indica Leaves Extracts. IJRAP. 2017;247-149.
Kawatu CB, Mongi J. Test on the effect of ethanol extract of anting-anting leaf (Acalypha indica L.) on blood sugar levels of male white mouse wistar (Rattus novergicus) (Uji Efek Ekstrak Etanol Daun Anting-Anting (Acalypha indica L.) Terhadap Kadar Gula Darah Tikus Putih Jantan Galur Wistar (Rattus novergicus). Pharmacon. 2013;81-85.
Antimicrobial, antioxidant activity and phytochemical screening of Acalypha indica crude leaf extract. Int. J. Pharm. Clin. Res. 2016;8(6):583-588.
Al Akeel R, Mateen A, Janardhan K, Gupta VC. Analysis of anti-bacterial and anti-oxidative activity of Azadirachta indica bark using various solvents extracts. Saudi Journal of Biological Sciences. 2017;24(1):11-14.
Mandokhail F, Jamil N, Riaz M, Masood Z, Ahmed S, Asif B, Sham-Ud-Din G, Noor G, Rehman N, Zahid S, Bano A, Dil Murad F, Shakeel D, Mengal F. Study of physica; and chemical properties of local neem (Azadirachta indica) soap with branded soaping relation to their impact on skin. Am-Euras. J. Toxicol. Sci. 20215;7(4):239-242.
Krishnasamyet A, Sundaresan M, Velan P. Rapid phytosynthesis of nano-sized titanium using leaf extract of Azadirachta indica. International Journal of Chem Tech Research. 2015;8(4):2047-2052.
Lakshmi T, Krishnan V, Rajendran R, Madhusudhanan N. Azadirachta indica: A herbal panacea in dentistry–An update. Pharmacognosy Reviews. 2015; 9(17):41.
Mak-Mensah EE, Firempong CK. Chemical characteristics of toilet soap prepared from neem (Azadirachta indica A. Juss) seed oil. Asian J Plant Sci Res. 2011;1(4):1-7.
Kumar SV, Kumar C, Vardhan A. Hepatoprotective activity of Acalypha indica Linn against thioacetamide-induced toxicity. Int J Pharm Pharm Sci. 2013;5:3–6.
Chekuri S, Panjala S, Anupalli RR. Cytotoxic activity of Acalypha indica L. hexane extract on breast cancer cell lines (MCF-7). J Phytopharmacol. 2017;6(5):264-268.
Wadhwani SA, Shedbalkar UU, Singh R, Chopade BA. Biogenic selenium nanoparticles: Current status and future prospects. Appl Microbiol Biotechnol. 2016;100:2555- 66.
Joshi SM, De Britto S, Jogaiah S, Ito SI. Mycogenic selenium nanoparticles as potential new generation broad spectrum antifungal molecules. Biomolecules. 2019;9:419.
Asghari-Paskiabi F, Imani M, Rafii-Tabar H, Razzaghi- Abyaneh M. Physicochemical properties, antifungal activity and cytotoxicity of selenium sulfide nanoparticles green synthesized by Saccharomyces cerevisiae. Biochem Biophys Res Commun. 2019;516: 1078-84.
Menon S, Agarwal H, Rajeshkumar S, Rosy PJ, Shanmugam VK. Investigating the antimicrobial activities of the biosynthesized selenium nanoparticles and its statistical analysis. Bio Nano Science; 2020.
Menon S, Devi KS, Santhiya R, Rajeshkumar S, Kumar V. Selenium nanoparticles: A potent chemotherapeutic agent and an elucidation of its mechanism. Colloids Surf B Biointerfaces. 2018;170:280-92.
Murugesan G, Nagaraj K, Sunmathi D, Subramani K. Methods involved in the synthesis of selenium nanoparticles and their different applications-a review. Eur J Biomed. 2019;6:189-94.
Umate SK, Marathe VR. Nutraceutical evaluation of Acalypha indica L. - A potential wild edible plant. International Journal of Green Pharmacy. 2018;12(3 Suppl.):510- 517.
Prem KK, Nirmala B, Rani AR. Antimicrobial, antioxidant activity and phytochemical screening of Acalypha indica Crude Leaf Extract. International Journal of Pharmaceutical and Clinical Research. 2016;8(6):583-588.
Nurul NMN, Norazlanshah H, Muhammad I, Mashita M, and Ayob MK. Preliminary studies on acalypha indica: proximate analysis and phytochemical screening. International Journal of Pharmacy and Pharmaceutical Sciences. 2016;8(3):406-408.
Chandrasekar R, Sivagami B. Alternative treatment for psoriasis - A review. International Journal of Research and Development in Pharmacy and Life Sciences. 2016;5.4:2188-2197.
Rajkiran Reddy Banala, Satish Kumar Vemuri, Gurava Reddy AV, Subbaiah GPV. Aqueous extract of Acalypha indica leaves for the treatment of Psoriasis: In-vitro studies. International Journal of Bioassays. 2017;6(04): 5360-5364.
Teklani PWNN, Perera BGK. The important biological activities and phytochemistry of Acalypha indica. International Journal of Research in Pharmacy and Science. 2016;6(1):30-35.
Mohan C, Dinakar S, Anand T. Phytochemical, GC-MS analysis and antibacterial activity of a medicinal plant Acalypha indica. Int J PharmTech Res. 2012;4:1050–4.
Prasad Paindla, Estari Mamidala: Phytochemical and chromatographic studies in the leaves extract of AcalyphaIndica: Online International Inter disciplinary Research Journal, {Bi Monthly}. 2014;IV(I):175-182. ISSN 2249-9598.
Paindla P, Mamidala E. Phytochemical and chromatographic studies in the leaves extract of Acalypha indica. Online Int Interdisciplinary Res J. 2014;4:175–82.
Selvamani S, Balamurugan S, Savitha G. Preliminary phytochemical screening and antibacterial activity of (Acalypha indica L). Int J Res Biol Sci. 2013;3:161–4.
Selvan R, Mohideen A, Sheriff M, Azmathullah N. Phytochemical screening of Acalypha indica L. leaf extracts. Int J Appl Biol Pharm Technol. 2012;3:158–61.
Mathew George, Lincy Joseph, Kamal Singh Vyas, Saira Susan Varghese. Anti arthritil activity of plant Acalypha indica. American Journal of Pharmacology and Pharmacotherapeucics. 2016;3(3):007–015.