Cancer prevention: Woman opts to have breasts, fallopian tubes removed to reduce risk

CINCINNATI (WKRC) - For those who have a family history of cancer or other illnesses, genetic testing can help a person determine steps to reduce risk.

For one woman, it’s led to a sense of empowerment.

Genetic testing showed Paola Holbrook was positive for the BRCA-1 gene, which put her at risk for breast cancer at about 80%. So, she chose to have both her breasts removed. But, she also learned something else.

“The BRCA-1 also contains a 40% risk for ovarian cancer. So, I went and made the decision to remove my fallopian tubes,” Holbrook said.

Just weeks later, it’s clear she’s inspiring others to take charge of their health at F45 Training in Library Township, where she works as a fitness coach.

“Just the fact that she's done this testing makes me think, 'maybe I should look into this for my family as well,'" said Carol Jamison, Co-Owner of F45 Training.

Holbrook's also paving the way for everyone to learn more information about changing their genetic risk for ovarian cancer.

She’s part of the SOROCk Trial.

In it, researchers are testing whether removal of the fallopian tubes, with the plan to remove the ovaries later, can reduce the risk of ovarian cancer to the same degree as the standard of care of removing both the ovaries and the fallopian tubes at the same time.

“It’s really a cutting-edge research study to determine what other options are available to these women, other than jumping to the most drastic steps possible,” said Corrie Fabelo, a genetic counseling supervisor at The Christ Hospital.

She's part of Holbrook’s genetic counseling team.

“We don’t always have prevention, but that’s the next steps in the future of genetics. How can we prevent all of these types of cancer and where will the research take us?” Fabelo said.

Holbrook said she already feels her cancer risks are reduced by having these preventative surgeries.

“Empowered, it’s one of those things where I get to determine my future on my terms and how I undertake this,” said Holbrook.

Talking to a genetic counselor can help a person decide which early screenings are recommended and which medications might be best for those at high risk.