The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation.
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28 kwi 2016 · Fn14 engagement as well as Fn14 overexpression can stimulate glioma cell migration, invasion and resistance to chemotherapeutic agents in ...
Tumor Necrosis Factor Receptor Superfamily Member 12A ... TweakR/Fn14 is a 129-aa type I transmembrane protein that is processed by signal peptidase into a mature ...
An effective treatment strategy for advanced melanoma thus remains a critical imperative. Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) and ...
21 wrz 2017 · TNFR-associated factors (TRAF) interact with Fn14, cellular inhibitor of apoptosis protein (cIAP)-1, and TNFR, consequently transducing signals ...
The protein product of the TNFRSF12A gene (fibroblast growth factor-inducible 14, or TWEAK receptor) is a receptor for the endogenous ligand TNF-like weak ...
The human Fn14 protein was recently identified as a cell-surface receptor for the tumour necrosis factor (TNF) superfamily member named TWEAK (TNF-like weak ...
1 gru 2008 · Abstract. The expression patterns of tumor necrosis factor-like weak inducer of apoptosis (TWEAK), a pleiotropic cytokine with ...
The levels of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor, fibroblast growth factor-inducible 14 protein (Fn14), are elevated ...
16 lis 2017 · Surprisingly, it was mediated by TWEAK interaction with CD163, a putative alternative TWEAK receptor. This neuronal death involved caspase-3 ...
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16 gru 2004 · The Fn14 gene encodes a type Ia transmembrane protein that belongs to the tumor necrosis factor receptor superfamily. We recently showed ...
22 cze 2010 · The Fn14 mRNA level in periodontitis tissue was significantly higher than that in healthy tissue. A moderate correlation between TWEAK/Fn14 ...
Description ... FN14 is expressed on a wide variety of different cell types and binds the ligand TWEAK (tumor necrosis factor-like weak inducer of apoptosis) to ...
14 cze 2017 · TWEAK, when binding to its initial receptor, fibroblast growth factor inducible molecule 14 (Fn14), exerts adverse biological functions in ...
The TNFRSF protein Fn14 is the Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) receptor. Fn14 was described in fibroblasts as Fibroblast Growth ...
TWEAK/Fn14 signaling in tumors - Guanglei Hu, Weihui Zeng, Yumin Xia, 2017
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22 cze 2017 · Currently, the tumor necrosis factor receptor–associated factor and nuclear factor kappa B signaling pathways are considered two main downstream ...
21 wrz 2017 · The aims of this review are to present the main results on TWEAK/Fn14 regulation of cell fates, to analyze the mechanism of the ...
... receptor binding, and soluble TWEAK is thus still able to interact with its receptor Fn14 and to trigger Fn14-associated signaling pathways (1). Fn14 is an ...
12 kwi 2010 · Tumour necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor Fn14 during cardiac remodelling in rats ... H. Ruskoaho, MD, PhD, ...
21 cze 2022 · Wang X, Xiao S, Xia Y. Tumor necrosis factor receptor mediates fibroblast growth factor-inducible 14 ssignaling. Cell Physiol Biochem. 2017;43: ...
The cytokine tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor fibroblast growth factor-inducible 14 (Fn14) are abundantly expressed ...
cytokine ; cardiac remodelling ; Fn14 ; TWEAK ; Tumor Necrosis Factors - genetics ; RNA, Messenger - metabolism ; Angiotensin II Type 1 Receptor Blockers ...
7 lut 2020 · The cytokine tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its functional receptor, fibroblast growth factor-inducible 14 ( ...
1 paź 2000 · Q9NP84 · TNR12_HUMAN. Protein. Tumor necrosis factor receptor superfamily member 12A. Gene. TNFRSF12A.
14 wrz 2018 · Fibroblast growth factor inducible 14 (Fn14) is a tumor necrosis factor (TNF) receptor family member that is strongly upregulated in response to ...
11 lut 2020 · The signaling induced by TNF superfamily receptors involves the presence of death domains in their cytoplasmic tail. However, the Fn14 ...
7 wrz 2022 · Binding of the cytokine TWEAK (tumor necrosis factor‐like weak inducer of apoptosis) to Fn14 leads to the activation of intracellular signaling ...
TNFRSF12A ; Gene location (Human) ; TNFRSF12A, CD266, FN14, TWEAKR, tumor necrosis factor receptor superfamily member 12A, TNF receptor superfamily member 12A.
The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-κB activation. Sharron A. N. ...
... necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor Fn14 has been recently shown to modulate cardiac ECM. TSP-4 null mice develop ...
Tumor necrosis factor (TNF)-like weak inducer of ... Fn14-expressing cells or activation of Fn14 by FcγR-bound antibody. ... By activation of its receptor Fn14, ...
Discussion. TWEAK and Fn14 are both abundantly expressed in the inflamed synovium of patients with (early) RA and PsA, where they may promote synovial ...
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) promotes glioblastoma cell chemotaxis via Lyn activation . Carcinogenesis. 2014. ;. 35. : 218. –.
6 kwi 2009 · Methods and Results— Herein, we demonstrate that mouse and human cardiomyocytes express the TWEAK receptor Fn14. Furthermore, we determine that ...
4 mar 2013 · In vitro, we demonstrated that TWEAK only inhibited ovarian cancer HO-8910PM cell proliferation in combination with tumor necrosis factor-α (TNF ...
Abstract. The cytokine tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) is a TNF superfamily member that is expressed by multiple cell ...
605914 - TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY, MEMBER 12A; TNFRSF12A - TYPE I TRANSMEMBRANE PROTEIN FN14; FN14;; TWEAK RECEPTOR; TWEAKR - TNFRSF12A.
TNFRSF12A is tumor necrosis factor receptor superfamily, member 12A. CD266,FN14,TWEAKR. Human TNFRSF12A 51330,Mouse Tnfrsf12a 27279,Rat Tnfrsf12a 302965 ...
Fn14 (fibroblast growth factor-inducible 14) protein/TWEAKR has been identified as the cell surface receptor for TWEAK. TWEAK/Fn14 signaling results in multiple ...
21 wrz 2017 · TWEAK/Fn14 interaction induces different cell fates depending on the local microenvironment, which correlates with certain expression profiles ...
22 wrz 2004 · ... neurons, both TWEAK and its receptor Fn14 were significantly upregulated. TWEAK induced cell death in primary neurons. Transfection of a ...
35 citations – A rabbit polyclonal antibody, raised against Tumor necrosis factor receptor superfamily member 12A (Human), supplied by Cell Signaling ...
28 kwi 2016 · Fibroblast growth factor-inducible 14 (Fn14; TNFRSF12A) is the cell surface receptor for the tumor necrosis factor (TNF) family member ...
15 lis 2007 · From the list of potential targets we selected TNFRSF12A/Fn14/TWEAK receptor, a tumor necrosis factor super-family receptor, for further ...
11 lis 2011 · Studies of Binding of Tumor Necrosis Factor ... receptor Fn14 and to trigger Fn14-associated signaling pathways ( ... For example, induction of Fn14 ...
21 gru 2018 · TWEAK, TNF receptor (TNFR)1, TNFR2, and TNFR superfamily member 12A mRNA, and TWEAK and Fn14 protein levels were increased by interleukin (IL)- ...
17 wrz 2009 · Objective— TWEAK is a multifunctional cytokine belonging to the tumor necrosis factor superfamily and binds to the receptor Fn14. TWEAK and ...
The tumor necrosis factor receptor superfamily (TNFRSF) is a protein superfamily of cytokine receptors characterized by the ability to bind tumor necrosis ...
21 kwi 2009 · Methods and Results— Herein, we demonstrate that mouse and human cardiomyocytes express the TWEAK receptor Fn14. Furthermore, we determine that ...
15 sty 2009 · ABSTRACT. Objective: To investigate the expression of tumour necrosis factor (TNF)-like weak inducer of apoptosis. (TWEAK) and its receptor ...
In situ hybridization analyses indicated that the Fn14 receptor is expressed in the granulosa and cumulus cells of preovulatory follicles and, to a lesser ...
... necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor Fn14 has been recently shown to modulate cardiac ECM. TSP-4 null mice develop ...
1 sty 2007 · The tumor necrosis factor (TNF) superfamily ... A sequence database search revealed that the predicted TWEAK receptor ... Recent studies have ...
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) contributes to dysfunction of endothelial cells via its receptor, Fn14. However, ...
11 gru 2009 · We assumed that TWEAK and its receptor Fn-14 could influ- ence the regulation of cytotoxic/immunotrophic pathways that are themselves under ...
CD266 | FN14 | TWEAKR. Gene Description, TNFRSF12A, tumor necrosis factor receptor superfamily member 12A, is a membrane receptor for Tnfsf12, which regulates ...
24 maj 2004 · Binds to FN14 and possibly also to TNRFSF12 ... Function. function. Binds to FN14 and possibly also to TNRFSF12/APO3. ... receptor ligand activity
23 kwi 2010 · The human Fn14 receptor gene is up-regulated in migrating glioma cells in vitro and overexpressed in advanced glial tumors. Am. J. Pathol ...
Ocena
(2) · 449,00 USD
... necrosis. These pathways are mediated by the binding of TWEAK by fibroblast growth factor 14 (Fn14), a member of the TNF receptor superfamily. Yeast two ...
25 kwi 2023 · Fas is a member of the tumor necrosis ... The TWEAK receptor Fn14 is a potential cell surface portal for targeted delivery of glioblastoma ...
Consistent with previous yeast two-hybrid and GST-FN14 pulldown studies, pulldown of FN14 with a TWEAK-Fc receptor fusion protein also brought down TRAF2 and ...
... receptor, Tweak-receptor, FGF inducible 14, FGF-inducible 14, Tumor necrosis factor receptor superfamily member 12A, Fibroblast growth factor inducible ...
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a cytokine that binds to the receptor fibroblast growth factor 14 (Fn14). The TWEAK/Fn14 ...
... necrosis, cell proliferation, and angiogenesis (2‑6). ... Fn14; FN14tumor necrosis factor receptor superfamily member ... receptor; type I transmembrane protein ...
TNF receptors that are Decoy Receptors; TNF receptor regulation; Tumor necrosis factor superfamily pathway. What proteins are included in the TNF superfamily?
Tested Applications: Flow Cytometry, Western, ELISA. Mouse monoclonal TWEAK Receptor/Fn-14 monoclonal antibody. 100% Bioguaranteed. ... Tumor necrosis factor ...
Ocena
· 490,00 USD
Monoclonal Fn14; Anti-Fn14; TNFRSF12A; Fn-14 ... The ITEM-4 antibody reacts with human TWEAK Receptor/Fn14. ... tumor necrosis factor receptor superfamily, member ...
Receptors, Tumor Necrosis Factor, Signal Transduction, Tumor Necrosis Factors. Citation. Permalink. https://hdl.handle.net/10161/11083. Published Version ...
Od 90,75 GBP do 190,00 GBP
TWEAK-induced cell death via Fn14 includes both apoptosis and necrosis and can be blocked by an anti-TWEAK antibody, CARL-1. Fn14 is expressed on HUVEC and ...
4 mar 2013 · Abstract. The aim of this current study was to investigate the expression of the tumor necrosis factor (TNF)-like weak inducer of.
A solid base of preclinical data suggests a role of therapies targeting the TWEAK or its receptor Fn14 in AKI and CKD. ... receptor Fn14. ... necrosis factor-like ...
... Fn14 receptor. Cytokine Growth Factor Rev 14:241–249 https://doi.org/10.1016/S1359-6101(03)00019-4; Wiley SR, Cassiano L, Lofton T et al (2001) A novel TNF ...
... receptor, Tweak-receptor, FGF inducible 14, FGF-inducible 14, Tumor necrosis factor receptor superfamily member 12A, Fibroblast growth factor inducible ...
My aim was to establish this effect in primary human skeletal muscle cells as well as to characterise the cytokine and its receptor Fn14. This year in ...
... Fn14 cytokine-receptor axis: discovery, biology ... receptor superfamilies: integrating mammalian biology ... necrosis factor-like weak inducer of apoptosis ...
... necrosis factor-like weak inducer of apoptosis ... Fn14 immediate-early response gene is induced ... receptor Fn14, is a novel regulator of mesenchymal ...
... Necrosis Factor Receptor Chromosomal Location ... FN14 8q24 ch15 TNFRSF11B 16p13.3 ch17 TNFRSF12A ... necrosis factor; TNFSF, tumor necrosis factor ...
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