Nov 4, 2022 · studied protein-conjugated NPs using lectins, gelatin, elastin, albumin, casein, and silk proteins and reported their preclinical and clinical ...

Nov 1, 2017 · We show herein that the cleavage of proDf into Df by MASP-1/3 can occur in the circulation and that inhibition of MASP-1/3 by gene silencing is ...

A conjugate of mitomycin C and the mannan of baker's yeast (Saccharomyces cerevisiae wild type strain) was synthesized. Assay of its growth inhibitory ...

Conjugate composed of a carrier and a drug covalently bound thereto, for use in the treatment of cancer, wherein the effective dose of anticancer drug used ...

This page is a summary of: Antitumor Activity of Mannan–Methotrexate Conjugate In Vitro and In Vivo , Oncology Research Featuring Preclinical and Clinical ...

The superior efficacy of mannosylated neoglycoprotein-conjugated methotrexate, compared with free drug, in eliminating the parasite burden in both the ...

Each mouse received a single dose iv (through the tail vein) of 0-2 mL conjugate (0-34 mg protein) ... Man-HSA-(3H)-MTX + Mannan. (1 mg/mL). Radioactivity.

Mannan-methotrexate conjugate showed significantly improved antitumor activity compared to free methotrexate in the model of P388 mouse leukemia disseminated in ...

WO2013127885A1 - A conjugate of methotrexate and hydroxyethyl starch for use in the treatment cancer - Google Patents. A conjugate of methotrexate and ...

Mannan-binding lectin (MBL), a component of the innate immune system, can bind to S. cerevisiae. MBL concentration depends on genetic polymorphisms. The aim of ...

This review outlines exclusive applications of mannose, mannan conjugates, and their specific interacting proteins (macrophage ... Mannan-methotrexate conjugate ...

... proteins by hepatic mannose receptors and mannan-binding protein. P. OpanasopitK. ShirashiM. NishikawaF. YamashitaY. TakakuraM. Hashida. Chemistry, Medicine.

There was no effect of Df siRNA treatment on MASP-3 protein in mice with CAIA (Fig. ... The conjugate of ... mannan-binding lectin, ficolins and associated proteins ...

In addition, we found that MTX-HSA had a delayed effect on the cell cycle compared with MTX and that this effect could be inhibited with the lysosomal inhibitor ...

A chemical modification of peptide and protein drugs ... conjugation to mannan: Implications in the immunotherapy of multiple sclerosis. ... conjugate for treatment ...

of a Monoclonal Antibody-Methotrexate Conjugate in Mice ... HSAj-MTX) as well as non protein-bound (free) MTX. ... Deglycosylation of ri- cin (11, 12) or host ...

The total protein concentration in the conjugate was calculated ... (BCA total protein) and 0.49% of unbound MTX. The ... Boratynski, Preparation of mannan–.

Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases. J Biol Chem. (2004) 279:26058–65. doi: 10.1074/jbc ...

apy (either azathioprine, 6-mercapto-purine, or methotrexate), ... Peroxidase-conjugated polyvalent anti-human immunoglobu- ... of mannan-binding protein in ...

In vivo recognition of mannosylated proteins by hepatic mannose receptors and serum mannan-binding protein (MBP) was investigated in mice.

Disease-associated Mutations in Human Mannose-binding Lectin Compromise Oligomerization and Activity of the Final Protein* ... methotrexate (MTX), dialyzed fetal ...

The antileishmanial potency of doxorubicin conjugated to mannose-human serum albumin. (man-HSA) was tested in experimental visceral leishmaniasis.

... injection with mannan, since approximate 200-fold ... methotrexate (MTX) (McCullough et al. ... In vivo recognition of mannosylated proteins by hepatic mannose ...

Jan 20, 2023 · Major Mannose-modified formulations used in chemotherapy are tabulated in Table 1. The acute leukemia drug methotrexate (MTX) in combination ...

The conjugates could make cancer drugs ... protein and anti-cancer drug · S. PrasadT. KumarA ... 2007. TLDR. Mannan-methotrexate conjugate showed significantly ...

number of mannose residues, and the dose adminis- ... Disposition characteristics of protein drugs in the ... tribution of methotrexate conjugated to mannosyl human ...

uptake is blocked by pre-injection with mannan, since ... at 320nm due to CPG2 cleavage of methotrexate (MTX) ... mannose receptors and mannan-binding protein. Am ...

... Protein (MBL/MBP) ... Mannan-methotrexate conjugate showed ASGP-R. ... Mannosylated Proteins as Cell-Specific Carriers Uptake of Polymeric Mannan-conjugates ...

Mar 18, 2020 · ... conjugating glycodendrimers on the multiple sites of a protein. ... Doores et al. showed that this synthetic mannose analog conjugated ...

Dec 18, 2023 · ... drugs in mannan NPs and their controlled release reduced the toxicity. ... Conclusion Direct injection of inflammatory proteins was assocd. with ...

Jan 9, 2017 · Antitumor activity of mannan-methotrexate conjugate in vitro and in vivo. Oncol Res 2007; 16: 415-421. [65] Blauchfield J, Toth I. Lipid ...

This procedure allows to conjugate anionic boron ... mannan-protein conjugates using high-temperature glycation. ... methotrexate conjugates. Anticancer Res 25(3B): ...

Jun 17, 2017 · ... methotrexate, or sulfasalazine ... dose, high dose, and especially combination biological drugs. ... mannan-binding protein. Immunogenetics. 1994 ...

Nov 17, 2023 · ... methotrexate-mannose conjugate nanoparticles with highly synergistic chemotherapeutic effects. J Mater Chem B . 2020; 8: 1922–34. OpenUrl ...

Conversely, the antitumor effects of free methotrexate and mannan-methotrexate conjugate were comparable when leukemia was implanted subcutaneously and ...

Mar 29, 2021 · ... methotrexate. rMASP-1, -2, and -3, rMAP-1 ... conjugated streptavidin and FITC-conjugated a-C3c pAb. ... Deposition of Mannan Binding Protein and ...

Oct 11, 2023 · ... conjugate drugs. (While the addition of ... Mannan, A.; Feng, Y. Antibody ... Methods for making conjugates from disulfide-containing proteins.

mannan-binding protein. Am J Physiol Gastrointest ... and liver targetability of methotrexate by conjugation with ... protein treatment, with little loss in ...

... protein conjugates. Adv. Drug Deliv. Rev. 2003 ... protein drugs. Br. J. Clin. Pharmacol. 2012, 74 ... Datta-Mannan, A.; Witcher, D.R.; Tang, Y.; Watkins, J ...

Jan 16, 2014 · immune cells from methotrexate ... the techniques for protein conjugation as well as chemical and ... can activate complement via the mannose- ...

08/23/2007, US20070197465 Hyaluronic Acid-Methotrexate Conjugate. 08/23/2007, US20070197428 Novel indications of mannan-binding lectin (MBL) in the treatment ...

scaffolds were conjugated with methotrexate at surface α-amino groups via a PVGLIG linker and ... protein mCherry-C1 ... mannan-coated superparamagnetic iron oxide.

Jan 9, 2017 · MTX Conjugate Nanocage Protein 2.9. MTX ... MTX conjugated to mannose to give Mann-MTX ... Antitumor activity of mannan-methotrexate conjugate in ...

A recombinant cytotoxic protein based on a combination of diphtheria toxin fragments and interleukin-2 used to treat cutaneous T-cell lymphoma by targeting the ...

2005. High-mannose-type glycan modifications of dihydrofolate reductase using glycan–methotrexate conjugates. K Totani, I Matsuo, Y Ihara, Y Ito. Bioorganic ...

Nov 1, 2022 · Mannosylated NPs and mannan-binding lectins/proteins (MBL/MBP) are emerging as promising tools for delivery of drugs, medicines, and enzymes to ...

serum-type mannan-binding protein, a specific lectin for the innate immune system, could also recognize D-mannose, L-fucose, and N-acetyl-D-glucosamine[251] ...

Jul 10, 2008 · ... proteins that possess two distinct ... Phorbol 12-myristate 13-acetate (PMA), methotrexate, mannose ... mannose-conjugated agarose. The materials ...

Mar 21, 2012 · conjugated mannose and β-cyclodextrin to ... methotrexate (MTX) ... 2005 Transmembrane delivery of protein and peptide drugs by TAT-mediated ...

Oct 12, 2021 · (such as organic solvents or DMSO), and ligands which may leach from affinity columns (e.g.. 11. Protein A or Protein G). For conjugated mAbs, ...

Mar 16, 2024 · Mediated Complement Activation by the Serum Mannan-Binding Protein.” Journal of Biological. 450. Chemistry 265(4): 1980–84. 451. Oroszlán ...

May 16, 2023 · catabolism operon regulatory protein, e) mannan degradation, f) mannuronate biosynthesis, g) propio- nate catabolism, h) arginine deiminase ...

... methotrexate or by using serum-free medium CHO ... Structure of a C-type mannose-binding protein complexed with an oligosaccharide. ... Dual functions: A coumarin– ...

... drugs. We tested several conjugates of MTX, namely with fibrinogen, albumin, glycated proteins, dextrans and mannan. They were studied both in vitro and in ...

(mannose)-binding protein (MBP) or mannan (mannose)-binding lectin (MBL), ... Dextran-methotrexate conjugate with the PVGLIG ... Involvement of serum mannan binding ...

Secondly, intracellular antibodies also called intrabodies that can be produced inside the tumor cells that inhibit the functions of oncogenic proteins (10).

Conventional conjugation procedures of mannan to proteins use oxidized mannan to release reactive aldehydes able to bind to free amino groups in the protein ...

Jan 8, 2013 · conjugated anti-CD45 (IgG1 ... were determined with a BCA protein Assay Reagent kit (Pierce). ... concomitant methotrexate. Arthritis Rheum 38 ...

Feb 7, 2018 · ... conjugate with a stable linker for the treatment of ... peptides and protein drugs. Br. J. Clin ... Datta-Mannan, A.; Witcher, D.R.; Tang, Y ...

Jan 13, 2018 · Synthesis and immunogenicity of polysaccharide–protein conjugate ... methotrexate in an oral dose ... Finally, the fluorescently labelled mannan ...

The Microbial Capsular Polysaccharide Galactoxylomannan Inhibits IL-17A Production in Circulating T Cells from Rheumatoid Arthritis Patients · Effect of GalXM on ...

A chemical modification of peptide and protein drugs improves ... conjugation to mannan: ... development of a novel non-RG cyclic peptide drug conjugate for ...

... Mannan A 1 ,. Choi H 2 ,. Stokell D 2 ,. Tang J 2 ... drugs and monoclonal antibody drug conjugates. ... Spatial mapping of protein composition and tissue ...

Mar 16, 2017 · Method: In RA patients eligible for biological treatment included in the BiOCURA registry, 53 inflammatory proteins ... blood tests, before the ...

The most commonly used polymers in PDN design include natural polymers [chitosan, dextran, dextrin, pullulan, mannan, proteins, hyaluronic acid]; synthetic ...

comparison to the protein content of the corresponding polymer-protein conjugate. ... mannan for drug delivery but not for protein ... glycol conjugated proteins ...

High-mannose-type glycan modifications of dihydrofolate reductase using glycan–methotrexate conjugates. K Totani, I Matsuo, Y Ihara, Y Ito. Bioorganic ...

... Methotrexate (MTX) ... protein secretion (black: GM-CSF; grey: IL-6 ... Mannan based-micelle systems with high stability were developed by grafting cholesterol ...

conjugated mouse monoclonal anti-human light chain IgG, IgM (Sigma), ... Methotrexate. 76. 65. Steroids. 38. 24. Plaquenil. 16. 27 ... Mannan binding protein in ...

cillin-streptomycin solution, methotrexate (MTX), dialyzed fetal bovine ... dilution of a streptavidin-horseradish peroxidase conjugate ... mation of the protein.

Sep 23, 2023 · e, f R69-4 failed to protect against mannan-induced psoriasis (MIP) or psoriatic arthritis in BQ. ... methotrexate (MTX). R69-4 might be a ...

Apr 26, 2018 · ... conjugation site. Therefore, Dau or methotrexate (MTX) were attached to the ε-amino group of 4Lys resulting in conjugates with two identical ...

Mar 12, 2022 · ... protein, mannan-binding lectin etc. Then a ... Folate receptor-targeted dendrimer-methotrexate conjugate for inflammatory arthritis. ... High-dose ...

Amita Datta-Mannan ... Micro- and mid-scale maleimide-based conjugation of cytotoxic drugs to antibody hinge region thiols for tumor targeting. ... Protein Sci.

The most widely used DMARD is methotrexate (MTX), a cornerstone of most treatment ... conjugated to digoxygenin ... Human mannan binding protein in pre-eclampsia.

May 5, 2022 · ... Mannan, A.; Feng, Y. ... CR011, a Fully Human Monoclonal Antibody-Auristatin E Conjugate, for the Treatment of Melanoma. ... Protein PMEL17 as a ...

dextrin, and mannan ... Protein thiolation and reversible protein-protein conjugation. ... Antitumor properties and toxicity of dextran-methotrexate conjugates are ...

... mannan, pullulan, amylopectin, dextran etc. ... proteins (immunocytokines) seem to be effective ... Folic acid conjugated guar gum nanoparticles for targeting ...

Feb 21, 2020 · serine protease-3; MAp19, Mannan-binding lectin-associated protein of 19. kDa; MAp44, Mannan-binding lectin-associated protein of 44 kDa [a.k.a.

MACE: methotrexate (MT. X), amsacrine, c y ta ... discontinuation or reduction in the dose of MBL. The MBL ... mannan-binding protein. J.Immunol. 155:3013-3020 ...

(2007). Antitumor activity of mannan-methotrexate conjugate in vitro and in vivo. Oncol Res 16: 415–421. 15. Goszczynski T, Nevozhay D, Wietrzyk J, Omar MS ...

... Treatment of patients with advanced pancreatic cancer harboring KRAS p.G12C mutant protein ... Conjugate with MMAE and LND1002 linker, 05/05/2021, Treatment ...

... conjugate used to treat HER2-overexpressing breast cancer. ... A fully human monoclonal IgG1 antibody directed against the GP1,2 surface protein of Zaire ...

Sep 5, 2022 · ... Mannan. A, Feng Y. Antibody ... conjugates: the nexus of bioorthogonal chemistry, protein ... conjugate for treatment of acute myeloid leukemia.

retinol binding protein, S100 protein, secretory immunoglobulin A (secretory IgA), soluble ... (IgM) conjugate antibody (Caprine) reagent, Human Immunoglobulin A ...

scaffolds were conjugated with methotrexate at surface α-amino groups via a PVGLIG linker and ... protein mCherry-C1 ... mannan-coated superparamagnetic iron oxide.

Nov 28, 2023 · quires the interaction of spike protein with C-type lectin recep- tors, we used mannan (a mannose polymer) to block the binding of spike ...

Jun 26, 2017 · Method: In RA patients eligible for biological treatment included in the BiOCURA registry, 53 inflammatory proteins ... blood tests, before the ...

Oct 9, 2015 · showed in 2002 that a branched polypeptide-methotrexate conjugate ... prepared carbohydrate (mannan ... carrier loaded with recombinant protein KMP- ...

Feb 11, 2022 · could be relevant for certain protein drugs, particularly conjugated and altered protein sequence drugs, where the cleavage products could ...

Methotrexate (MTX) conjugated with maleylated bovine serum albumin (MBSA) was administered to the L. Mexicana infected hamsters. Due to localized infection ...

G Protein-Coupled Receptor Class C Group 5 Member D ... mannan-binding lectin-associated serine protease-2 ... methotrexate. NDA, = new drug application. NHL, = non ...

conjugate (1:10,000; LI-COR biosciences). As a ... layer is enriched for glycosylated proteins (mannan), and the inner layer consists ... Plasma membrane MDR/MFS ...

... protein degradation that occurs in the disease. ... mannan (WAM025). In contrast, diisopropylfluorophosphate, a ... Methotrexate Conjugate. HIRAKU ONISHI, TSUNEJI ...

Methotrexate · Mice · Mice, Inbred BALB C · Mice ... Receptor Protein-Tyrosine Kinases · Receptor, erbB ... People in same department with this person. Nouri, ...

Studies on the biological and antitumor properties of conjugates of methotrexate (MTX) with macromolecular carriers (dextran, mannan, fibrinogen, albumin).

... Mannan- binding lectin serine protease. B, Activation of ... C- reactive protein in rheumatology. Arthritis ... methotrexate. Ann Rheum Dis 2015;74:333–40. 26 ...

Treatment of Charcot-Marie-Tooth disease type 1A. Murigenetics SAS. 15, 14, Bcl-2 Family Protein Inhibitor, 12/19/2007, Treatment of small cell lung cancer ...

Streptavidin, agarose conjugate. 16-126 ... protein-protein interaction studies and many other applications. ... Methotrexate−Agarose. M0269.