Executive summary Far-reaching changes to the structure and function of the Earth's natural
systems represent a growing threat to human health. And yet, global health has mainly …

Background To curb the spread of the COVID-19 (coronavirus disease 2019) pandemic, the
world needs diagnostic systems capable of rapid detection and quantification of the novel …

Background Non-fatal outcomes of disease and injury increasingly detract from the ability of
the world's population to live in full health, a trend largely attributable to an epidemiological …

Reverse genetics has been an indispensable tool to gain insights into viral pathogenesis
and vaccine development. The genomes of large RNA viruses, such as those from …

Centrifuge is a novel microbial classification engine that enables rapid, accurate, and
sensitive labeling of reads and quantification of species on desktop computers. The system …

Zoonotic spillover, which is the transmission of a pathogen from a vertebrate animal to a
human, presents a global public health burden but is a poorly understood phenomenon …

Seven years after the declaration of the first epidemic of Ebola virus disease in Guinea, the
country faced a new outbreak—between 14 February and 19 June 2021—near the …

Without an approved vaccine or treatments, Ebola outbreak management has been limited
to palliative care and barrier methods to prevent transmission. These approaches, however …

Abstract The recent Ebola and Zika epidemics demonstrate the need for the continuous
surveillance, rapid diagnosis and real-time tracking of emerging infectious diseases. Fast …

In its largest outbreak, Ebola virus disease is spreading through Guinea, Liberia, Sierra
Leone, and Nigeria. We sequenced 99 Ebola virus genomes from 78 patients in Sierra …