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Sp-04 * international patterns of palliative care in neuro-oncology: a physician survey of members of the asian society of neuro-oncology, the european association of neuro-oncology and the society for neuro-oncology
CONCLUSION: This is the first report describing global differences of PC utilization in neuro-oncology. Significant differences in provider training, culture, access and utilization were mainly found between AO and the US or AO and Europe. PC patterns are more similar in Europe and the US.
Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Walbert, T., Puduvalli, V., Taphoorn, M. J. B., Taylor, A. R., Jalali, R. Tags: SUPPORTIVE AND PALLIATIVE CARE Source Type: research

Practical Approach to the Tele-Neuro-Ophthalmology and Neuro-Otology Visits: Instructional Videos
Abstract: A collection of instructional videos that illustrate a step by step approach to tele-neuro-ophthalmology and neuro-otology visits. These videos provide instruction for patient preparation for their video visit, patient and provider interface with an electronic medical record associated video platform, digital applications to assist with vision testing, and practical advice for detailed remote neuro-ophthalmologic and neuro-otologic examinations.
Source: Journal of Neuro-Ophthalmology - February 25, 2021 Category: Opthalmology Tags: Technology in Neuro-Ophthalmology Source Type: research

Impact of nuclear distribution element genes in the typical and atypical antipsychotics effects on nematode Caenorhabditis elegans: Putative animal model for studying the pathways correlated to schizophrenia
Publication date: Available online 19 December 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Gabriela Guilherme Monte, João V. Nani, Marina Rosseto de Almeida Campos, Caroline Dal Mas, Lucas Augusto Negri Marins, Lucas Gelain Martins, Ljubica Tasic, Marcelo A. Mori, Mirian A.F. HayashiAbstractThe nuclear distribution element genes are conserved from fungus to humans. The nematode Caenorhabditis elegans expresses two isoforms of nuclear distribution element genes, namely nud-1 and nud-2. While nud-1 was functionally demonstrated to be the worm nudC ortholog, bioinformatic analysis rev...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - December 20, 2018 Category: Psychiatry Source Type: research

Nonvolatile WORM and rewritable multifunctional resistive switching memory devices from poly(4-vinyl phenol) and 2-amino-5-methyl-1,3,4-thiadiazole composite
Publication date: 25 October 2019Source: Journal of Alloys and Compounds, Volume 806Author(s): Yanmei Sun, Dianzhong WenAbstractA multifunctional resistive switching memory devices with the typical sandwich structure of Al/Poly(4-vinylphenol) (PVP)+2-Amino-5-methyl-1,3,4-thiadiazole/Al is fabricated. Al as the bottom and top electrodes is easy to realize by simple thermal evaporation process, and a PVP and 2-Amino-5-methyl-1,3,4-thiadiazole composite film as the active layer is prepared by sol-gel method and spin coating process. The as-fabricated resistive switching memory device shows write-once-read-many (WORM) and rewr...
Source: Journal of Alloys and Compounds - July 28, 2019 Category: Chemistry Source Type: research

Drug screens of NGLY1 deficiency in worm and fly models reveal catecholamine, NRF2 and anti-inflammatory-pathway activation as potential clinical approaches RESEARCH ARTICLE
ABSTRACT N-glycanase 1 (NGLY1) deficiency is an ultra-rare and complex monogenic glycosylation disorder that affects fewer than 40 patients globally. NGLY1 deficiency has been studied in model organisms such as yeast, worms, flies and mice. Proteasomal and mitochondrial homeostasis gene networks are controlled by the evolutionarily conserved transcriptional regulator NRF1, whose activity requires deglycosylation by NGLY1. Hypersensitivity to the proteasome inhibitor bortezomib is a common phenotype observed in whole-animal and cellular models of NGLY1 deficiency. Here, we describe unbiased phenotypic drug screens to identi...
Source: DMM Disease Models and Mechanisms - November 3, 2019 Category: Biomedical Science Authors: Iyer, S., Mast, J. D., Tsang, H., Rodriguez, T. P., DiPrimio, N., Prangley, M., Sam, F. S., Parton, Z., Perlstein, E. O. Tags: Rare diseases, Model Systems in Drug Discovery, Drosophila as a Disease Model RESEARCH ARTICLE Source Type: research

Toward integrative 'omics of the barber's pole worm and related parasitic nematodes.
Abstract Advances in nucleic acid sequencing, mass spectrometry and computational biology have facilitated the identification, annotation and analysis of genes, transcripts, proteins and metabolites in model nematodes (Caenorhabditis elegans and Pristionchus pacificus) and socioeconomically important parasitic nematodes (Clades I, III, IV and V). Significant progress has been made in genomics and transcriptomics as well as in the proteomics and lipidomics of Haemonchus contortus (the barber's pole worm) - one of the most pathogenic representatives of the order Strongylida. Here, we review salient aspects of genomi...
Source: Infection, Genetics and Evolution - August 10, 2020 Category: Genetics & Stem Cells Authors: Ma G, Gasser RB, Wang T, Korhonen PK, Young ND Tags: Infect Genet Evol Source Type: research

A new case definition of Neuro-Inflammatory and Oxidative Fatigue (NIOF), a neuroprogressive disorder, formerly known as chronic fatigue syndrome or Myalgic Encephalomyelitis: results of multivariate pattern recognition methods and external validation by neuro-immune biomarkers.
Authors: Maes M Abstract BACKGROUND: Chronic fatigue syndrome (CFS) or Myalgic Encephalomyelitis (ME) is characterized by neuro-psychiatric (e.g. depression, irritability, sleep disorders, autonomic symptoms and neurocognitive defects) and physio-somatic (fatigue, a flu-like malaise, hyperalgesia, irritable bowel, muscle pain and tension) symptoms. New ME/CFS case definitions based on consensus criteria among experts are largely inadequate, e.g. those of the US Institute of Medicine . OBJECTIVES: The aim of the present study was to delineate a new case definition of ME/CFS based on pattern recognition methods a...
Source: Neuroendocrinology Letters - October 12, 2015 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Peristalsis and propulsion of colonic content can occur after blockade of major neuro-neuronal and neuro-muscular transmitters in isolated guinea-pig colon.
In this study we investigated whether blockade of the major receptors that underlie excitatory neuro-muscular transmission are required for hexamethonium-resistant peristalsis to occur. Methods: Video imaging of colonic wall movements was used to make spatio-temporal maps and determine the velocity of peristalsis. Propagation of artificial fecal pellets in the guinea-pig distal colon was studied in hexamethonium, atropine, ω-conotoxin (GVIA), ibodutant (MEN15596) and tetrodotoxin (TTX). Results: Hexamethonium and ibodutant alone did not retard peristalsis. In contrast, ω-conotoxin abolished peristalsis in a proportion of...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - October 10, 2013 Category: Physiology Authors: Sia TC, Brookes SJ, Dinning PG, Wattchow DA, Spencer NJ Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

Structure of neuro-endocrine and neuro-epithelial interactions in human foetal pancreas.
Abstract In the pancreas of many mammals including humans, endocrine islet cells can be integrated with the nervous system components into neuro-insular complexes. The mechanism of the formation of such complexes is not clearly understood. The present study evaluated the interactions between the nervous system components, epithelial cells and endocrine cells in the human pancreas. Foetal pancreas, gestational age 19-23 weeks (13 cases) and 30-34 weeks (7 cases), were studied using double immunohistochemical labeling with neural markers (S100 protein and beta III tubulin), epithelial marker (cytokeratin 19 (CK19)) ...
Source: Tissue and Cell - October 25, 2016 Category: Cytology Authors: Krivova Y, Proshchina A, Barabanov V, Leonova O, Saveliev S Tags: Tissue Cell Source Type: research

Small things in life: A tiny worm and $1.8 million NIH grant help gene expression research
(Kansas State University) A teeny, tiny worm and a $1.8 million National Institutes of Health grant may help a Kansas State University researcher understand how the smallest molecules can have big effects on gene expression.
Source: EurekAlert! - Medicine and Health - December 13, 2017 Category: International Medicine & Public Health Source Type: news

Race To Eradicate Guinea Worm And Polio Experienced Roadblocks In 2017
This year, the world came tantalizingly close to wiping out two human diseases: Guinea worm and polio. But right at the finish line, both eradication projects have run into surprising roadblocks.
Source: NPR Health and Science - December 25, 2017 Category: Consumer Health News Authors: Michaeleen Doucleff Source Type: news

Resveratrol ameliorates lipopolysaccharide-induced anxiety-like behavior by attenuating YAP-mediated neuro-inflammation and promoting hippocampal autophagy in mice.
Abstract Resveratrol, a type of natural polyphenol mainly extracted from the skin of grapes, has been reported to protect against inflammatory responses and exert anxiolytic effect. Yes-associated protein (YAP), a major downstream effector of the Hippo signaling pathway, plays a critical role in inflammation. The present study aimed to explore whether YAP pathway was involved in the anxiolytic effect of resveratrol in lipopolysaccharide (LPS)-treated C57BL/6 J male mice. LPS treatment induced anxiety-like behavior and decreased sirtuin 1 while increased YAP expression in the hippocampus. Resveratrol attenuated L...
Source: Toxicology and Applied Pharmacology - September 29, 2020 Category: Toxicology Authors: Tian Q, Fan X, Ma J, Han Y, Li D, Jiang S, Zhang F, Guang H, Shan X, Chen R, Wang P, Wang Q, Yang J, Wang Y, Hu L, Shentu Y, Gong Y, Fan J Tags: Toxicol Appl Pharmacol Source Type: research

Effects of selective TNFR1 inhibition or TNFR2 stimulation, compared to non-selective TNF inhibition, on (neuro)inflammation and behavior after myocardial infarction in male mice.
CONCLUSION: Early receptor interventions, but not non-specific TNF inhibition, increased mortality. Apart from this undesired effect, the general beneficial profile after TNFR2 stimulation, rather than the unfavourable effects of TNFR1 inhibition, would render TNFR2 stimulation preferable over non-specific TNF inhibition in MI with comorbid depression. However, follow-up studies regarding optimal timing and dosing are needed. PMID: 33444731 [PubMed - as supplied by publisher]
Source: Brain, Behavior, and Immunity - January 11, 2021 Category: Neurology Authors: Gouweleeuw L, Wajant H, Maier O, Eisel ULM, Blankesteijn WM, Schoemaker RG Tags: Brain Behav Immun Source Type: research

Beta-caryophyllene, a CB2R selective agonist, protects against cognitive impairment caused by neuro-inflammation and not in dementia due to ageing induced by mitochondrial dysfunction.
CONCLUSION: Hence, we conclude that β-caryophyllene at 100 mg/kg protects against dementia induced by neuro-inflammation with no effect on neuronal aging induced by mitochondrial dysfunction. PMID: 33530917 [PubMed - as supplied by publisher]
Source: CNS and Neurological Disorders Drug Targets - February 2, 2021 Category: Drugs & Pharmacology Authors: Kanojia U, Chaturbhuj SG, Sankhe R, Das M, Surubhotla R, Krishnadas N, Gourishetti K, Nayak PG, Kishore A Tags: CNS Neurol Disord Drug Targets Source Type: research

Nc-13 * cranial radiation encompassing the genu is associated with neuro-psychological sequelae in children: a prospective study of diffusion tensor imaging (dti) and proton mr spectroscopy (mrs)
CONCLUSIONS: The genu is a region with increased susceptibility to injury associated with neuro-psychological sequelae. Efforts should be made to limit radiation dose to this region during treatment planning.
Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Redmond, K., Mahone, M., Sair, H., Vannorsdall, T., Terezakis, S., Kleinberg, L., McNutt, T., Wharam, M., Horska, A. Tags: NEURO-COGNITIVE AND FUNCTIONAL OUTCOMES Source Type: research