Complex disease by definition results from the interplay of genetic and environmental
factors. However, it is currently unclear how gene-environment interaction can best be used …

Background Whether exposure to air pollution adversely affects the growth of lung function
during the period of rapid lung development that occurs between the ages of 10 and 18 …

Asthma is a common disease with a complex risk architecture including both genetic and
environmental factors. We performed a meta-analysis of North American genome-wide …

A cohort of 1,678 Southern California children, enrolled as fourth graders in 1996, was
followed for 4 years to determine whether the growth in lung function of the children was …

Background Little is known about the effect of exposure to air pollution during exercise or
time spent outdoors on the development of asthma. We investigated the relation between …

Background Whether local exposure to major roadways adversely affects lung-function
growth during the period of rapid lung development that takes place between 10 and 18 …

The analysis of gene-environment interaction (G× E) may hold the key for further
understanding the etiology of many complex traits. The current availability of high-volume …

Background Air-pollution levels have been trending downward progressively over the past
several decades in southern California, as a result of the implementation of air quality …

Consideration of gene–environment (G× E) interaction is becoming increasingly important in
the design of new epidemiologic studies. We present a method for computing required …

In the study of complex diseases, it may be important to test hypotheses related to gene-
gene (G× G) interaction. The success of such studies depends critically on obtaining …

Background: Evidence for a causal relationship between traffic-related air pollution and
asthma has not been consistent across studies, and comparisons among studies have been …

To determine the relation between obesity and new-onset asthma among school-age
children, the authors examined longitudinal data from 3,792 participants in the Children's …

We review case-control designs for studying gene associations in which relatives of case
patients are used as control subjects. These designs have the advantage that they avoid the …

Personal exposure to environmental substances is largely determined by time–
microenvironment–activity patterns while moving across locations or microenvironments …

To study the possible chronic respiratory effects of air pollutants, we designed and initiated a
10-yr prospective study of Southern California public schoolchildren living in 12 …

BACKGROUND Exposure to environmental tobacco smoke (ETS) during childhood and in
utero exposure to maternal smoking are associated with adverse effects on lung growth and …

To study possible chronic respiratory effects of air pollutants, we initiated a 10-yr prospective
cohort study of Southern California children, with a study design focused on four pollutants …

Background The question of whether air pollution contributes to asthma onset remains
unresolved. Objectives In this study, we assessed the association between asthma onset in …

To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-
genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence …

The rise in childhood asthma prevalence suggests a role for environmental factors in the
etiology of this evolving epidemic; however, genetics also influence the occurrence of …